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Placental growth factor testing for suspected pre‐eclampsia: a cost‐effectiveness analysis

Duhig, KE; Seed, PT; Myers, J; Bahl, R; Bambridge, G; Barnfield, S; Ficquet, J; Girling, J; Khalil, A; Shennan, AH; et al. Duhig, KE; Seed, PT; Myers, J; Bahl, R; Bambridge, G; Barnfield, S; Ficquet, J; Girling, J; Khalil, A; Shennan, AH; Chappell, LC; Hunter, R (2019) Placental growth factor testing for suspected pre‐eclampsia: a cost‐effectiveness analysis. BJOG, 126 (11). pp. 1390-1398. ISSN 1471-0528 https://doi.org/10.1111/1471-0528.15855
SGUL Authors: Khalil, Asma

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Abstract

Objective To calculate the cost‐effectiveness of implementing PlGF testing alongside a clinical management algorithm in maternity services in the UK, compared with current standard care. Design Cost‐effectiveness analysis. Setting Eleven maternity units participating in the PARROT stepped‐wedge cluster‐randomised controlled trial. Population Women presenting with suspected pre‐eclampsia between 20+0 and 36+6 weeks’ gestation. Methods Monte Carlo simulation utilising resource use data and maternal adverse outcomes. Main outcome measures Cost per maternal adverse outcome prevented. Results Clinical care with PlGF testing costs less than current standard practice and resulted in fewer maternal adverse outcomes. There is a total cost‐saving of UK£149 per patient tested, when including the cost of the test. This represents a potential cost‐saving of UK£2,891,196 each year across the NHS in England. Conclusions Clinical care with PlGF testing is associated with the potential for cost‐savings per participant tested when compared with current practice via a reduction in outpatient attendances, and improves maternal outcomes. This economic analysis supports a role for implementation of PlGF testing in antenatal services for the assessment of women with suspected pre‐eclampsia. Tweetable abstract Placental growth factor testing for suspected pre‐eclampsia is cost‐saving and improves maternal outcomes.

Item Type: Article
Additional Information: © 2019 The Authors BJOG: An International Journal of Obstetrics and Gynaecology published by John Wiley & Sons Ltd on behalf of Royal College of Obstetricians and Gynaecologists This is an open access article under the terms of the Creative Commons Attribution (http://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Keywords: Economic Analysis, Placental Growth Factor, Preeclampsia, 11 Medical And Health Sciences, Obstetrics & Reproductive Medicine
SGUL Research Institute / Research Centre: Academic Structure > Molecular and Clinical Sciences Research Institute (MCS)
Journal or Publication Title: BJOG
ISSN: 1471-0528
Language: eng
Dates:
DateEvent
4 September 2019Published
17 July 2019Published Online
10 June 2019Accepted
Publisher License: Creative Commons: Attribution 4.0
Projects:
Project IDFunderFunder ID
PB-PG-0214-3305National Institute for Health Researchhttp://dx.doi.org/10.13039/501100000272
RP-2014-05-019National Institute for Health Researchhttp://dx.doi.org/10.13039/501100000272
PubMed ID: 31240854
Go to PubMed abstract
URI: https://openaccess.sgul.ac.uk/id/eprint/111035
Publisher's version: https://doi.org/10.1111/1471-0528.15855

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