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Pulse Pressure Relationships with Demographics and Kidney Function in Ashanti, Ghana

Banerjee, D; Plange-Rhule, J; Chitalia, N; Kumi, K; Micah, FB; Cappuccio, FP; Eastwood, JB (2018) Pulse Pressure Relationships with Demographics and Kidney Function in Ashanti, Ghana. INTERNATIONAL JOURNAL OF HYPERTENSION, 2018. p. 7864564. ISSN 2090-0384 https://doi.org/10.1155/2018/7864564
SGUL Authors: Eastwood, John Bannister Banerjee, Debasish

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Abstract

Introduction. Hypertension, particularly pulse pressure [PP] is a major risk factor for end-stage renal disease. However, the effect of individual components of hypertension namely PP, systolic [SBP] and diastolic blood pressure [DBP] on kidney function, in the general African population is unknown. Methods. Data were collected on 944 participants [aged 40-75 y], living in villages in the area around the city of Kumasi, Ghana, on demographics, medications, height, weight, BP and 24-hour creatinine clearance (CrCl). Results. The demographic and clinical characteristics were: age 55(11) [mean (SD)] years, females 62%, rural village-dwellers 52%, diabetes 1·5%, BMI 21(4) kg/m2, 24-hourCrCl as a measure of glomerular filtration rate (GFR) 84(23) ml/min/1.73 m2. 29% had BP >140/90 mmHg; SBP and DBP were 125/74(26/14) mmHg, PP was 51(17) mmHg. PP increased with age by 0.55(95% CI: 0.46,0.64) mmHg/year. PP was higher (53(17) v 49(15) mmHg; p < 0.001) in the semiurban participants. GFR decreased both with increasing PP [-0.19 (-0.27,-0.10 ml/min/1.73 m2/mmHg; p < 0.001] and SBP [-0.09 (-0.14,-0.03) ml/min/1.73 m2/mmHg; p < 0.001] but there was no significant relationship with DBP [-0.04 (-0.15,0.06)]. After adjusting for SBP, the relationship between GFR and PP became steeper [-0.31 (-0.50,-0.12) ml/min/1.73 m2/mmHg; p < 0.001]. Using multivariate regression analysis that included PP, age, gender, BMI, only increasing age [-0.75 (-0.88,-0.62)] and decreasing BMI [0.49 (0.16,0.81)] were associated with decreased kidney function. Conclusions. In this homogeneous West-African population, PP increased with age and had a steeper relationship with declining kidney function than SBP or DBP.

Item Type: Article
Additional Information: Copyright © 2018 Debasish Banerjee et al. This is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
SGUL Research Institute / Research Centre: Academic Structure > Institute of Medical & Biomedical Education (IMBE)
Academic Structure > Molecular and Clinical Sciences Research Institute (MCS)
Journal or Publication Title: INTERNATIONAL JOURNAL OF HYPERTENSION
ISSN: 2090-0384
Dates:
DateEvent
4 October 2018Published
16 September 2018Accepted
Projects:
Project IDFunderFunder ID
060415/Z/00/ZWellcome Trusthttp://dx.doi.org/10.13039/100004440
069500/Z/02/ZWellcome Trusthttp://dx.doi.org/10.13039/100004440
Web of Science ID: WOS:000447517700001
URI: https://openaccess.sgul.ac.uk/id/eprint/110312
Publisher's version: https://doi.org/10.1155/2018/7864564

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