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Soil-transmitted helminth parasites and allergy: Observations from Ecuador.

Chico, ME; Vaca, MG; Rodriguez, A; Cooper, PJ (2019) Soil-transmitted helminth parasites and allergy: Observations from Ecuador. Parasite Immunol, 41 (6). e12590. ISSN 1365-3024 https://doi.org/10.1111/pim.12590
SGUL Authors: Cooper, Philip John

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Abstract

There is considerable interest as to potential protective effects of soil-transmitted helminths (STH) against allergy and allergic diseases. Here, we discuss findings of studies done of the effects of STH parasites on atopy and allergic diseases in Ecuador. While cross-sectional studies have consistently shown a reduced prevalence of allergen skin prick test (SPT) reactivity among infected schoolchildren, the removal of these infections by repeated deworming did not affect SPT prevalence over the short-term (ie, 12 months) but may have increased SPT prevalence over the long-term (ie, 15-17 years). In the case of allergic symptoms, cross-sectional studies have generally not shown associations with STH and intervention studies showed no impact on prevalence. However, a birth cohort suggested that early STH infections might reduce wheeze by 5 years. Allergic sensitization to Ascaris, however, explained a significant proportion of wheezing among rural schoolchildren. Studies of the effects of STH on immune and inflammatory responses indicated a potential role of STH in contributing to more robust regulation. The effects of STH on allergy are likely to be determined by history of exposure over the life-course and by interactions with a wide variety of other infectious and non-infectious factors.

Item Type: Article
Additional Information: © 2018 The Authors. Parasite Immunology Published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Keywords: 0605 Microbiology, 1108 Medical Microbiology, 0707 Veterinary Sciences, Mycology & Parasitology
SGUL Research Institute / Research Centre: Academic Structure > Infection and Immunity Research Institute (INII)
Journal or Publication Title: Parasite Immunol
ISSN: 1365-3024
Language: eng
Dates:
DateEvent
20 May 2019Published
17 October 2018Published Online
12 September 2018Accepted
Publisher License: Creative Commons: Attribution 4.0
Projects:
Project IDFunderFunder ID
074679/Z/04/ZWellcome Trusthttp://dx.doi.org/10.13039/100004440
080013/Z/06/ZWellcome Trusthttp://dx.doi.org/10.13039/100004440
088862/Z/09/ZWellcome Trusthttp://dx.doi.org/10.13039/100004440
PubMed ID: 30229947
Go to PubMed abstract
URI: https://openaccess.sgul.ac.uk/id/eprint/110255
Publisher's version: https://doi.org/10.1111/pim.12590

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