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(2018)
Genetic analysis of over one million people identifies 535 new loci associated with blood pressure traits.
Nature Genetics, 50 (10).
pp. 1412-1425.
ISSN 1546-1718
https://doi.org/10.1038/s41588-018-0205-x
SGUL Authors: Strachan, David Peter
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Abstract
High blood pressure is a highly heritable and modifiable risk factor for cardiovascular disease. We report the largest genetic association study of blood pressure traits (systolic, diastolic, pulse pressure) to date in over one million people of European ancestry. We identify 535 novel blood pressure loci that not only offer new biological insights into blood pressure regulation but also reveal shared genetic architecture between blood pressure and lifestyle exposures. Our findings identify new biological pathways for blood pressure regulation with potential for improved cardiovascular disease prevention in the future.
| Item Type: | Article | ||||||||
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| Additional Information: | This is a post-peer-review, pre-copyedit version of an article published in Nature Genetics. The final authenticated version is available online at: http://dx.doi.org/10.1038/s41588-018-0205-x Correction available at: http://doi.org/10.1038/s41588-018-0297-3 | ||||||||
| Keywords: | Developmental Biology, 11 Medical And Health Sciences, 06 Biological Sciences | ||||||||
| SGUL Research Institute / Research Centre: | Academic Structure > Population Health Research Institute (INPH) | ||||||||
| Journal or Publication Title: | Nature Genetics | ||||||||
| ISSN: | 1546-1718 | ||||||||
| Dates: |
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| Publisher License: | Publisher's own licence | ||||||||
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| URI: | https://openaccess.sgul.ac.uk/id/eprint/109959 | ||||||||
| Publisher's version: | https://doi.org/10.1038/s41588-018-0205-x |
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