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Small vessels, dementia and chronic diseases – molecular mechanisms and pathophysiology

Horsburgh, K; Wardlaw, JM; van Agtmael, T; Allan, SM; Ashford, MLJ; Bath, PM; Brown, R; Berwick, J; Cader, MZ; Carare, RO; et al. Horsburgh, K; Wardlaw, JM; van Agtmael, T; Allan, SM; Ashford, MLJ; Bath, PM; Brown, R; Berwick, J; Cader, MZ; Carare, RO; Davis, JB; Duncombe, J; Farr, TD; Fowler, JH; Goense, RO; Granata, A; Hall, CN; Hainsworth, AH; Harvey, A; Hawkes, CA; Joutel, A; Kalaria, RN; Kehoe, PG; Lawrence, CB; Lockhart, A; Love, S; Macleod, MR; Macrae, IM; Markus, HS; McCabe, C; McColl, BW; Meakin, PJ; Miller, A; Nedergaard, M; O'Sullivan, M; Quinn, TJ; Rajani, R; Saksida, LM; Smith, C; Smith, KJ; Touyz, RM; Trueman, RC; Wang, T; Williams, A; Williams, SCR; Work, LM (2018) Small vessels, dementia and chronic diseases – molecular mechanisms and pathophysiology. CLINICAL SCIENCE, 132 (8). pp. 851-868. ISSN 0143-5221 https://doi.org/10.1042/CS20171620
SGUL Authors: Hainsworth, Atticus Henry

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Abstract

Cerebral small vessel disease (SVD) is a major contributor to stroke, cognitive impairment and dementia with limited therapeutic interventions. There is a critical need to provide mechanistic insight and improve translation between pre-clinical research and the clinic. A 2-day workshop was held which brought together experts from several disciplines in cerebrovascular disease, dementia and cardiovascular biology, to highlight current advances in these fields, explore synergies and scope for development. These proceedings provide a summary of key talks at the workshop with a particular focus on animal models of cerebral vascular disease and dementia, mechanisms and approaches to improve translation. The outcomes of discussion groups on related themes to identify the gaps in knowledge and requirements to advance knowledge are summarized.

Item Type: Article
Additional Information: © 2018 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society
Keywords: Cardiovascular System & Hematology, 11 Medical And Health Sciences
SGUL Research Institute / Research Centre: Academic Structure > Molecular and Clinical Sciences Research Institute (MCS)
Journal or Publication Title: CLINICAL SCIENCE
ISSN: 0143-5221
Dates:
DateEvent
30 April 2018Published
8 February 2018Accepted
URI: https://openaccess.sgul.ac.uk/id/eprint/109781
Publisher's version: https://doi.org/10.1042/CS20171620

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