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NF-κB Activity Initiates Human ESC-Derived Neural Progenitor Cell Differentiation by Inducing a Metabolic Maturation Program.

FitzPatrick, LM; Hawkins, KE; Delhove, JMKM; Fernandez, E; Soldati, C; Bullen, LF; Nohturfft, A; Waddington, SN; Medina, DL; Bolaños, JP; et al. FitzPatrick, LM; Hawkins, KE; Delhove, JMKM; Fernandez, E; Soldati, C; Bullen, LF; Nohturfft, A; Waddington, SN; Medina, DL; Bolaños, JP; McKay, TR (2018) NF-κB Activity Initiates Human ESC-Derived Neural Progenitor Cell Differentiation by Inducing a Metabolic Maturation Program. Stem Cell Reports, 10 (6). pp. 1766-1781. ISSN 2213-6711 https://doi.org/10.1016/j.stemcr.2018.03.015
SGUL Authors: Nohturfft, Axel

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Abstract

Human neural development begins at embryonic day 19 and marks the beginning of organogenesis. Neural stem cells in the neural tube undergo profound functional, morphological, and metabolic changes during neural specification, coordinated by a combination of exogenous and endogenous cues. The temporal cell signaling activities that mediate this process, during development and in the postnatal brain, are incompletely understood. We have applied gene expression studies and transcription factor-activated reporter lentiviruses during in vitro neural specification of human pluripotent stem cells. We show that nuclear factor κB orchestrates a multi-faceted metabolic program necessary for the maturation of neural progenitor cells during neurogenesis.

Item Type: Article
Additional Information: © 2018 The Authors. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
Keywords: NF-κB signaling, autophagy, cell cycle, human embryonic development, metabolism, neurogenesis
SGUL Research Institute / Research Centre: Academic Structure > Institute of Medical & Biomedical Education (IMBE)
Academic Structure > Institute of Medical & Biomedical Education (IMBE) > Centre for Biomedical Education (INMEBE)
Journal or Publication Title: Stem Cell Reports
ISSN: 2213-6711
Language: eng
Dates:
DateEvent
5 June 2018Published
19 April 2018Published Online
20 March 2018Accepted
Publisher License: Creative Commons: Attribution-Noncommercial-No Derivative Works 4.0
Projects:
Project IDFunderFunder ID
260862European Research Councilhttp://dx.doi.org/10.13039/501100000781
NC/L001780/1National Centre for the Replacement, Refinement and Reduction of Animals in Researchhttp://dx.doi.org/10.13039/501100000849
G1000709Medical Research Councilhttp://dx.doi.org/10.13039/501100000265
MR/N026101/1Medical Research Councilhttp://dx.doi.org/10.13039/501100000265
MR/R015325/1Medical Research Councilhttp://dx.doi.org/10.13039/501100000265
MR/P026494/1Medical Research Councilhttp://dx.doi.org/10.13039/501100000265
MR/N019075/1Medical Research Councilhttp://dx.doi.org/10.13039/501100000265
SAF2016-78114-RMINECOUNSPECIFIED
CB16/10/00282CIBERFESUNSPECIFIED
608381SP3-People-MC-ITNUNSPECIFIED
666918Horizon 2020UNSPECIFIED
17UCL01SPARKSUNSPECIFIED
PubMed ID: 29681545
Go to PubMed abstract
URI: https://openaccess.sgul.ac.uk/id/eprint/109750
Publisher's version: https://doi.org/10.1016/j.stemcr.2018.03.015

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