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Temporal Association Between Rhinovirus Activity and Kingella kingae Osteoarticular Infections.

Droz, N; Enouf, V; Bidet, P; Mohamed, D; Behillil, S; Simon, A-L; Bachy, M; Caseris, M; Bonacorsi, S; Basmaci, R (2018) Temporal Association Between Rhinovirus Activity and Kingella kingae Osteoarticular Infections. J Pediatr, 192. 234-239.e2. ISSN 1097-6833 https://doi.org/10.1016/j.jpeds.2017.09.052
SGUL Authors: Basmaci, Romain

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Abstract

OBJECTIVE: To determine whether the seasonal distribution of Kingella kingae osteoarticular infections is similar to that of common respiratory viruses. STUDY DESIGN: Between October 2009 and September 2016, we extracted the results of K kingae-specific real-time polymerase chain reaction analyses performed for bone or joint specimens in patients from 2 pediatric tertiary care centers in Paris. We used data of respiratory virus detection from the Réseau National des Laboratoires network with coordination with the National Influenza Center of France. The Spearman rank correlation was used to assess a correlation between weekly distributions, with P < .05 denoting a significant correlation. RESULTS: During the 7-year study period, 322 children were diagnosed with K kingae osteoarticular infection, and 317 testing episodes were K kingae-negative. We observed high activity for both K kingae osteoarticular infection and human rhinovirus (HRV) during the fall (98 [30.4%] and 2401 [39.1%] cases, respectively) and low activity during summer (59 [18.3%] and 681 [11.1%] cases, respectively). Weekly distributions of K kingae osteoarticular infection and rhinovirus activity were significantly correlated (r = 0.30; P = .03). In contrast, no significant correlation was found between the weekly distribution of K kingae osteoarticular infection and other respiratory viruses (r = -0.17, P = .34 compared with respiratory syncytial virus; r = -0.13, P = .34 compared with influenza virus; and r = -0.22, P = .11 compared with metapneumovirus). CONCLUSION: A significant temporal association was observed between HRV circulation and K kingae osteoarticular infection, strengthening the hypothesis of a role of viral infections in the pathophysiology of K kingae invasive infection.

Item Type: Article
Additional Information: © 2017. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
Keywords: bone and joint infections, children, respiratory viruses, seasonal distribution, viral–bacterial interaction, Arthritis, Infectious, Child, Preschool, France, Humans, Infant, Kingella kingae, Neisseriaceae Infections, Picornaviridae Infections, Real-Time Polymerase Chain Reaction, Rhinovirus, Seasons, bone and joint infections, children, respiratory viruses, seasonal distribution, viral–bacterial interaction, Pediatrics, 1114 Paediatrics And Reproductive Medicine, 1106 Human Movement And Sports Science
SGUL Research Institute / Research Centre: Academic Structure > Infection and Immunity Research Institute (INII)
Journal or Publication Title: J Pediatr
ISSN: 1097-6833
Language: eng
Dates:
DateEvent
January 2018Published
12 December 2017Published Online
21 September 2017Accepted
Publisher License: Creative Commons: Attribution-Noncommercial-No Derivative Works 4.0
PubMed ID: 29246347
Go to PubMed abstract
URI: https://openaccess.sgul.ac.uk/id/eprint/109593
Publisher's version: https://doi.org/10.1016/j.jpeds.2017.09.052

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