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Neurobiology of functional (psychogenic) movement disorders.

Edwards, MJ; Fotopoulou, A; Pareés, I (2013) Neurobiology of functional (psychogenic) movement disorders. Curr Opin Neurol, 26 (4). pp. 442-447. ISSN 1473-6551 https://doi.org/10.1097/WCO.0b013e3283633953
SGUL Authors: Edwards, Mark John James

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Abstract

PURPOSE OF REVIEW: This review explores recent developments in understanding the neurobiological mechanism of functional (psychogenic) movement disorders (FMDs). This is particularly relevant given the resurgence of academic and clinical interest in patients with functional neurological symptoms and the clear shift in diagnostic and treatment approaches away from a pure psychological model of functional symptoms. RECENT FINDINGS: Recent research findings implicate three key processes in the neurobiology of FMD (and by extension other functional neurological symptoms): abnormal attentional focus, abnormal beliefs and expectations, and abnormalities in sense of agency. These three processes have been combined in recent neurobiological models of FMD in which abnormal predictions related to movement are triggered by self-focused attention, and the resulting movement is generated without the normal sense of agency that accompanies voluntary movement. SUMMARY: New understanding of the neurobiology of FMD forms an important part of reappraising the way that patients with FMD (and other functional disorders) are characterized and treated. It also provides a testable framework for further exploring the pathophysiology of these common causes of ill health.

Item Type: Article
Additional Information: This is an open access article distributed under the Creative Commons Attribution License 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by-nc-nd/4.0.
Keywords: Attention, Culture, Humans, Models, Biological, Movement Disorders, Neurobiology, Humans, Movement Disorders, Attention, Neurobiology, Models, Biological, Culture, conversion disorder, functional neurological symptoms, neurobiology, psychogenic, Neurology & Neurosurgery, 1103 Clinical Sciences, 1109 Neurosciences, 1702 Cognitive Science
SGUL Research Institute / Research Centre: Academic Structure > Molecular and Clinical Sciences Research Institute (MCS)
Academic Structure > Molecular and Clinical Sciences Research Institute (MCS) > Neuroscience (INCCNS)
Journal or Publication Title: Curr Opin Neurol
ISSN: 1473-6551
Language: eng
Dates:
DateEvent
August 2013Published
PubMed ID: 23823467
Web of Science ID: WOS:000326816800016
Go to PubMed abstract
URI: https://openaccess.sgul.ac.uk/id/eprint/109509
Publisher's version: https://doi.org/10.1097/WCO.0b013e3283633953

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