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Amyloid Oligomers as Blood Biomarkers in the Diagnosis of Alzheimer’s Disease

Aggrey, R; Matharu, B; Mehr, A; Lawrence, R; Austen, BM (2017) Amyloid Oligomers as Blood Biomarkers in the Diagnosis of Alzheimer’s Disease. SciFed Journal of Neuroscience, 1 (1). p. 1000008.
SGUL Authors: Austen, Brian Maxwell

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Abstract

Oligomeric forms of the peptide, β-amyloid, (Aβ) are known to be toxic to human and rodent neurones, and have been identified as possible causative agents in the loss of cognitive function in Alzheimer’s Disease (AD). An ELISA assay has been developed capable of detecting oligomeric forms of Aβ in biological fluids, but not detecting monomeric species. The ELISA has been validated with a number of synthetic variant sequences of Aβ and the effects of known inhibitors of Aβ oligomer formation. Significantly raised levels of oligomers were detected in sera samples from AD patients, compared to age-matched control sera.

Item Type: Article
Additional Information: © 2017 Brian Austen. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
SGUL Research Institute / Research Centre: Academic Structure > Institute of Medical & Biomedical Education (IMBE)
Academic Structure > Institute of Medical & Biomedical Education (IMBE) > Centre for Biomedical Education (INMEBE)
Journal or Publication Title: SciFed Journal of Neuroscience
Dates:
DateEvent
27 October 2017Published
7 October 2017Accepted
Publisher License: Creative Commons: Attribution 4.0
URI: http://openaccess.sgul.ac.uk/id/eprint/109467

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