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Disproportionate cardiac hypertrophy during early postnatal development in infants born preterm.

Aye, CYL; Lewandowski, AJ; Lamata, P; Upton, R; Davis, E; Ohuma, EO; Kenworthy, Y; Boardman, H; Wopperer, S; Packham, A; et al. Aye, CYL; Lewandowski, AJ; Lamata, P; Upton, R; Davis, E; Ohuma, EO; Kenworthy, Y; Boardman, H; Wopperer, S; Packham, A; Adwani, S; McCormick, K; Papageorghiou, AT; Leeson, P (2017) Disproportionate cardiac hypertrophy during early postnatal development in infants born preterm. Pediatr Res, 82 (1). pp. 36-46. ISSN 1530-0447 https://doi.org/10.1038/pr.2017.96
SGUL Authors: Papageorghiou, Aris

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Abstract

Background Adults born very preterm have increased cardiac mass and reduced function. We investigated whether a hypertrophic phenomenon occurs in later preterm infants and when this occurs during early development. Methods Cardiac ultrasound was performed on 392 infants (33% preterm at mean gestation 34±2 weeks). Scans were performed during fetal development in 137, at birth and 3 months of postnatal age in 200, and during both fetal and postnatal development in 55. Cardiac morphology and function was quantified and computational models created to identify geometric changes. Results At birth, preterm offspring had reduced cardiac mass and volume relative to body size with a more globular heart. By 3 months, ventricular shape had normalized but both left and right ventricular mass relative to body size were significantly higher than expected for postmenstrual age (left 57.8±41.9 vs. 27.3±29.4%, P<0.001; right 39.3±38.1 vs. 16.6±40.8, P=0.002). Greater changes were associated with lower gestational age at birth (left P<0.001; right P=0.001). Conclusion Preterm offspring, including those born in late gestation, have a disproportionate increase in ventricular mass from birth up to 3 months of postnatal age. These differences were not present before birth. Early postnatal development may provide a window for interventions relevant to long-term cardiovascular health.

Item Type: Article
Additional Information: This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ © The Author(s) (2017)
Keywords: Pediatrics, 1114 Paediatrics And Reproductive Medicine
SGUL Research Institute / Research Centre: Academic Structure > Institute of Medical & Biomedical Education (IMBE)
Academic Structure > Institute of Medical & Biomedical Education (IMBE) > Centre for Clinical Education (INMECE )
Journal or Publication Title: Pediatr Res
ISSN: 1530-0447
Language: eng
Dates:
DateEvent
July 2017Published
24 May 2017Published Online
20 March 2017Accepted
Publisher License: Creative Commons: Attribution 4.0
Projects:
Project IDFunderFunder ID
099973/Z/12/ZWellcome Trusthttp://dx.doi.org/10.13039/100004440
FS/11/65/28865British Heart Foundationhttp://dx.doi.org/10.13039/501100000274
PubMed ID: 28399117
Go to PubMed abstract
URI: https://openaccess.sgul.ac.uk/id/eprint/109166
Publisher's version: https://doi.org/10.1038/pr.2017.96

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