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The association between fibrinogen reactivity to mental stress and high-sensitivity cardiac troponin T in healthy adults.

Lazzarino, AI; Hamer, M; Gaze, D; Collinson, P; Rumley, A; Lowe, G; Steptoe, A (2015) The association between fibrinogen reactivity to mental stress and high-sensitivity cardiac troponin T in healthy adults. Psychoneuroendocrinology, 59. pp. 37-48. ISSN 1873-3360 https://doi.org/10.1016/j.psyneuen.2015.05.002
SGUL Authors: Collinson, Paul

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Abstract

BACKGROUND: Plasma fibrinogen is considered as a positive mediator between mental stress and cardiovascular disease because it is an acute-phase protein released in response to mental stress and a coagulation factor. However those three factors have never been studied together within a single integrated framework, using cardiac troponin T as a marker of cardiovascular risk. METHODS: 491 disease-free men and women aged 53-76 were tested for fibrinogen levels before, immediately after, and following recovery from standardized mental stress tasks. We measured plasma cardiac troponin T using a high-sensitivity assay (HS-CTnT) and coronary calcification using electron-beam dual-source computed tomography. RESULTS: The average fibrinogen concentration increased by 5.1% (s.d.=7.3) in response to stress and then tended to return to baseline values. People with higher baseline fibrinogen values had smaller increases (blunted responses) following the stress task (P=0.001), and people with higher stress responses showed better recovery (P<0.001). In unadjusted analyses, higher baseline fibrinogen was associated with higher chances of having detectable HS-CTnT (P=0.072) but, conversely, higher fibrinogen response was associated with lower chances of having detectable HS-CTnT (P=0.007). The adjustment for clinical, inflammatory, and haemostatic factors, as well as for coronary calcification eliminated the effect of baseline fibrinogen, whereas the negative association between fibrinogen response and HS-CTnT remained robust: the odds of detectable HS-CTnT halved for each 10% increase in fibrinogen concentration due to stress (OR=0.49, P=0.007, 95% CI=0.30-0.82). CONCLUSIONS: Greater fibrinogen responses to mental stress are associated with lower likelihood of detectable high-sensitivity troponin T plasma concentration. A more dynamic fibrinogen response appears to be advantageous for cardiovascular health.

Item Type: Article
Additional Information: © 2015 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
Keywords: Allostasis, Atherosclerosis, Fibrinogen, Psychological, Stress, Troponin T, Aged, Biomarkers, Cardiovascular Diseases, Female, Fibrinogen, Humans, Male, Middle Aged, Risk Factors, Stress, Psychological, Troponin T, Humans, Cardiovascular Diseases, Fibrinogen, Troponin T, Risk Factors, Stress, Psychological, Aged, Middle Aged, Female, Male, Biomarkers, Stress, Psychological, Fibrinogen, Troponin T, Atherosclerosis, Allostasis, Psychiatry, 11 Medical And Health Sciences, 17 Psychology And Cognitive Sciences
SGUL Research Institute / Research Centre: Academic Structure > Molecular and Clinical Sciences Research Institute (MCS)
Academic Structure > Molecular and Clinical Sciences Research Institute (MCS) > Cardiac (INCCCA)
Journal or Publication Title: Psychoneuroendocrinology
ISSN: 1873-3360
Language: eng
Dates:
DateEvent
September 2015Published
14 May 2015Published Online
6 May 2015Accepted
Publisher License: Creative Commons: Attribution-Noncommercial-No Derivative Works 4.0
Projects:
Project IDFunderFunder ID
RG/10/005/28296British Heart FoundationUNSPECIFIED
UNSPECIFIEDBritish Heart FoundationUNSPECIFIED
PubMed ID: 26010862
Web of Science ID: WOS:000358099100004
Go to PubMed abstract
URI: https://openaccess.sgul.ac.uk/id/eprint/108957
Publisher's version: https://doi.org/10.1016/j.psyneuen.2015.05.002

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