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The effect of depression and side effects of antiepileptic drugs on injuries in patients with epilepsy

Gur-Ozmen, S; Mula, M; Agrawal, N; Cock, HR; Lozsadi, DA; von Oertzen, TJ (2017) The effect of depression and side effects of antiepileptic drugs on injuries in patients with epilepsy. European Journal of Neurology, 24 (9). pp. 1135-1139. ISSN 1468-1331 https://doi.org/10.1111/ene.13346
SGUL Authors: Cock, Hannah Rutherford Von Oertzen, Tim

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Abstract

Background and purpose People with epilepsy are at increased risk of accidents and injuries but, despite several studies on this subject, data regarding preventable causes are still contradictory. The aim of this study was to investigate the relationship between injuries, side effects of antiepileptic drugs (AEDs) and depression. Methods Data from a consecutive sample of adult patients with epilepsy attending the outpatient clinics at St George's University Hospital in London were included. All patients were asked if they had had any injury since the last clinic appointment and completed the Liverpool Adverse Event Profile (LAEP) and Neurological Disorders Depression Inventory for Epilepsy. Results Among 407 patients (243 females, mean age 43.1 years), 71 (17.4%) reported injuries since the last appointment. A two-step cluster analysis revealed two clusters with the major cluster (53.5% of the injured group) showing a total score for LAEP ≥45, a positive Neurological Disorders Depression Inventory for Epilepsy screening and presence of AED polytherapy. A total score for LAEP ≥45 was the most important predictor. Conclusions Antiepileptic drug treatment should be reviewed in patients reporting injuries in order to evaluate the potential contribution and burden of AED side effects.

Item Type: Article
Additional Information: This is the peer reviewed version of the following article: Gur-Ozmen, S., Mula, M., Agrawal, N., Cock, H. R., Lozsadi, D. and von Oertzen, T. J. (2017), The effect of depression and side effects of antiepileptic drugs on injuries in patients with epilepsy. Eur J Neurol, 24: 1135–1139., which has been published in final form at http://doi.org/10.1111/ene.13346. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
Keywords: Neurology & Neurosurgery, 1103 Clinical Sciences, 1109 Neurosciences
SGUL Research Institute / Research Centre: Academic Structure > Institute of Medical & Biomedical Education (IMBE)
Academic Structure > Institute of Medical & Biomedical Education (IMBE) > Centre for Clinical Education (INMECE )
Journal or Publication Title: European Journal of Neurology
ISSN: 1468-1331
Dates:
DateEvent
14 August 2017Published
20 July 2017Published Online
22 May 2017Accepted
Publisher License: Publisher's own licence
URI: https://openaccess.sgul.ac.uk/id/eprint/108864
Publisher's version: https://doi.org/10.1111/ene.13346

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