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Group B Streptococcus and Respiratory Syncytial Virus immunisation during pregnancy: a landscape analysis

Heath, PT; Culley, FJ; Jones, CE; Kampmann, B; Le Doare, K; Nunes, M; Sadarangani, M; Chaudhry, Z; Baker, CJ; Openshaw, PJ (2017) Group B Streptococcus and Respiratory Syncytial Virus immunisation during pregnancy: a landscape analysis. LANCET INFECTIOUS DISEASES, 17 (7). e223-e234. ISSN 1473-3099 https://doi.org/10.1016/S1473-3099(17)30232-3
SGUL Authors: Jones, Christine Elizabeth Le Doare, Kirsty

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Abstract

Group B streptococcus and respiratory syncytial virus are leading causes of infant morbidity and mortality worldwide. No licensed vaccines are available for either disease, but vaccines for both are under development. Severe respiratory syncytial virus disease can be prevented by passively administered antibody. The presence of maternal IgG antibody specific to respiratory syncytial virus is associated with reduced prevalence and severity of respiratory syncytial virus disease in the first few weeks of life, whereas maternal serotype-specific anticapsular antibody is associated with protection against both early-onset and late-onset group B streptococcus disease. Therefore, vaccination in pregnancy might protect infants against both diseases. This report describes what is known about immune protection against group B streptococcus and respiratory syncytial virus, identifies knowledge gaps regarding the immunobiology of both diseases, and aims to prioritise research directions in maternal immunisation.

Item Type: Article
Additional Information: © 2017. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
Keywords: Microbiology, 1103 Clinical Sciences, 1108 Medical Microbiology
SGUL Research Institute / Research Centre: Academic Structure > Infection and Immunity Research Institute (INII)
Journal or Publication Title: LANCET INFECTIOUS DISEASES
ISSN: 1473-3099
Dates:
DateEvent
7 February 2017Accepted
19 April 2017Published Online
July 2017Published
Publisher License: Creative Commons: Attribution-Noncommercial-No Derivative Works 4.0
Projects:
Project IDFunderFunder ID
UNSPECIFIEDWellcome Trusthttp://dx.doi.org/10.13039/100004440
UNSPECIFIEDRosetrees Trusthttp://dx.doi.org/10.13039/501100000833
UNSPECIFIEDStoneygate TrustUNSPECIFIED
UNSPECIFIEDMedical Research Councilhttp://dx.doi.org/10.13039/501100000265
UNSPECIFIEDComprehensive Local Research NetworkUNSPECIFIED
UNSPECIFIEDNational Institute for Health Researchhttp://dx.doi.org/10.13039/501100000272
UNSPECIFIEDBiomedical Research CentreUNSPECIFIED
URI: https://openaccess.sgul.ac.uk/id/eprint/108591
Publisher's version: https://doi.org/10.1016/S1473-3099(17)30232-3

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