SORA

Advancing, promoting and sharing knowledge of health through excellence in teaching, clinical practice and research into the prevention and treatment of illness

Placental growth factor as a marker of fetal growth restriction caused by placental dysfunction.

Benton, SJ; McCowan, LM; Heazell, AEP; Grynspan, D; Hutcheon, JA; Senger, C; Burke, O; Chan, Y; Harding, JE; Yockell-Lelièvre, J; et al. Benton, SJ; McCowan, LM; Heazell, AEP; Grynspan, D; Hutcheon, JA; Senger, C; Burke, O; Chan, Y; Harding, JE; Yockell-Lelièvre, J; Hu, Y; Chappell, LC; Griffin, MJ; Shennan, AH; Magee, LA; Gruslin, A; von Dadelszen, P (2016) Placental growth factor as a marker of fetal growth restriction caused by placental dysfunction. Placenta, 42. pp. 1-8. ISSN 1532-3102 https://doi.org/10.1016/j.placenta.2016.03.010
SGUL Authors: von Dadelszen, Peter Magee, Laura Ann

[img]
Preview
PDF Published Version
Available under License Creative Commons Attribution Non-commercial No Derivatives.

Download (570kB) | Preview

Abstract

INTRODUCTION: Discriminating between placentally-mediated fetal growth restriction and constitutionally-small fetuses is a challenge in obstetric practice. Placental growth factor (PlGF), measurable in the maternal circulation, may have this discriminatory capacity. METHODS: Plasma PlGF was measured in women presenting with suspected fetal growth restriction (FGR; ultrasound fetal abdominal circumference <10th percentile for gestational age) at sites in Canada, New Zealand and the United Kingdom. When available, placenta tissue underwent histopathological examination for lesions indicating placental dysfunction, blinded to PlGF and clinical outcome. Lesions were evaluated according to pre-specified severity criteria and an overall severity grade was assigned (0-3, absent to severe). Low PlGF (concentration <5th percentile for gestational age) to identify placental FGR (severity grade≥2) was assessed and compared with routine parameters for fetal assessment. For all cases, the relationship between PlGF and the sampling-to-delivery interval was determined. RESULTS: Low PlGF identified placental FGR with an area under the receiver-operator characteristic curve of 0.96 [95% CI 0.93-0.98], 98.2% [95% CI 90.5-99.9] sensitivity and 75.1% [95% CI 67.6-81.7] specificity. Negative and positive predictive values were 99.2% [95% CI 95.4-99.9] and 58.5% [95% CI 47.9-68.6], respectively. Low PlGF outperformed gestational age, abdominal circumference and umbilical artery resistance index in predicting placental FGR. Very low PlGF (<12 pg/mL) was associated with shorter sampling-to-delivery intervals than normal PlGF (13 vs. 29.5 days, P < 0.0001). DISCUSSION: Low PlGF identifies small fetuses with significant underlying placental pathology and is a promising tool for antenatal discrimination of FGR from fetuses who are constitutionally-small.

Item Type: Article
Additional Information: © 2016 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
Keywords: Diagnosis, Fetal growth restriction, Placental dysfunction, Placental growth factor, Placental lesions, Fetal growth restriction, Placental growth factor, Placental dysfunction, Placental lesions, Diagnosis, Diagnosis, Fetal growth restriction, Placental dysfunction, Placental growth factor, Placental lesions, Obstetrics & Reproductive Medicine, 1103 Clinical Sciences, 1114 Paediatrics And Reproductive Medicine
SGUL Research Institute / Research Centre: Academic Structure > Molecular and Clinical Sciences Research Institute (MCS)
Journal or Publication Title: Placenta
ISSN: 1532-3102
Language: ENG
Dates:
DateEvent
1 June 2016Published
23 March 2016Published Online
21 March 2016Accepted
Publisher License: Creative Commons: Attribution-Noncommercial-No Derivative Works 4.0
Projects:
Project IDFunderFunder ID
MOC 119545Canadian Institutes of Health Researchhttp://dx.doi.org/10.13039/501100000024
OPP1017337Bill and Melinda Gates Foundationhttp://dx.doi.org/10.13039/100000865
PubMed ID: 27238707
Web of Science ID: WOS:000376517400001
Go to PubMed abstract
URI: https://openaccess.sgul.ac.uk/id/eprint/108347
Publisher's version: https://doi.org/10.1016/j.placenta.2016.03.010

Actions (login required)

Edit Item Edit Item