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Comparison of 3 T and 1.5 T for T2* magnetic resonance of tissue iron.

Alam, MH; Auger, D; McGill, L-A; Smith, GC; He, T; Izgi, C; Baksi, AJ; Wage, R; Drivas, P; Firmin, DN; et al. Alam, MH; Auger, D; McGill, L-A; Smith, GC; He, T; Izgi, C; Baksi, AJ; Wage, R; Drivas, P; Firmin, DN; Pennell, DJ (2016) Comparison of 3 T and 1.5 T for T2* magnetic resonance of tissue iron. Journal of Cardiovascular Magnetic Resonance, 18 (1). p. 40. ISSN 1532-429X https://doi.org/10.1186/s12968-016-0259-9
SGUL Authors: He, Taigang

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Abstract

BACKGROUND: T2* magnetic resonance of tissue iron concentration has improved the outcome of transfusion dependant anaemia patients. Clinical evaluation is performed at 1.5 T but scanners operating at 3 T are increasing in numbers. There is a paucity of data on the relative merits of iron quantification at 3 T vs 1.5 T. METHODS: A total of 104 transfusion dependent anaemia patients and 20 normal volunteers were prospectively recruited to undergo cardiac and liver T2* assessment at both 1.5 T and 3 T. Intra-observer, inter-observer and inter-study reproducibility analysis were performed on 20 randomly selected patients for cardiac and liver T2*. RESULTS: Association between heart and liver T2* at 1.5 T and 3 T was non-linear with good fit (R (2) = 0.954, p < 0.001 for heart white-blood (WB) imaging; R (2) = 0.931, p < 0.001 for heart black-blood (BB) imaging; R (2) = 0.993, p < 0.001 for liver imaging). R2* approximately doubled between 1.5 T and 3 T with linear fits for both heart and liver (94, 94 and 105 % respectively). Coefficients of variation for intra- and inter-observer reproducibility, as well as inter-study reproducibility trended to be less good at 3 T (3.5 to 6.5 %) than at 1.5 T (1.4 to 5.7 %) for both heart and liver T2*. Artefact scores for the heart were significantly worse with the 3 T BB sequence (median 4, IQR 2-5) compared with the 1.5 T BB sequence (4 [3-5], p = 0.007). CONCLUSION: Heart and liver T2* and R2* at 3 T show close association with 1.5 T values, but there were more artefacts at 3 T and trends to lower reproducibility causing difficulty in quantifying low T2* values with high tissue iron. Therefore T2* imaging at 1.5 T remains the gold standard for clinical practice. However, in centres where only 3 T is available, equivalent values at 1.5 T may be approximated by halving the 3 T tissue R2* with subsequent conversion to T2*.

Item Type: Article
Additional Information: © 2016 The Author(s). Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
Keywords: 3 T, Heart, Iron overload, Liver, Magnetic resonance, Siderosis, T2*, Magnetic resonance, 3 T, Heart, Liver, Iron overload, Siderosis, T2*, 3 T, Heart, Iron overload, Liver, Magnetic resonance, Siderosis, T2*, Nuclear Medicine & Medical Imaging, 1102 Cardiovascular Medicine And Haematology
SGUL Research Institute / Research Centre: Academic Structure > Molecular and Clinical Sciences Research Institute (MCS)
Academic Structure > Molecular and Clinical Sciences Research Institute (MCS) > Cardiac (INCCCA)
Journal or Publication Title: Journal of Cardiovascular Magnetic Resonance
ISSN: 1532-429X
Language: ENG
Dates:
DateEvent
8 July 2016Published
22 June 2016Accepted
Publisher License: Creative Commons: Attribution-No Derivative Works 4.0
Projects:
Project IDFunderFunder ID
UNSPECIFIEDNational Institutes of Healthhttp://dx.doi.org/10.13039/100000002
PubMed ID: 27391316
Web of Science ID: WOS:000379550300001
Go to PubMed abstract
URI: https://openaccess.sgul.ac.uk/id/eprint/108331
Publisher's version: https://doi.org/10.1186/s12968-016-0259-9

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