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Anti-arthritic actions of β-cryptoxanthin against the degradation of articular cartilage in vivo and in vitro

Imada, K; Tsuchida, A; Ogawa, K; Sofat, N; Nagase, H; Ito, A; Sato, T (2016) Anti-arthritic actions of β-cryptoxanthin against the degradation of articular cartilage in vivo and in vitro. Biochemical and Biophysical Research Communications, 476 (4). pp. 352-358. ISSN 0006-291X https://doi.org/10.1016/j.bbrc.2016.05.126
SGUL Authors: Sofat, Nidhi

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Abstract

An inverse correlation between the morbidity of rheumatoid arthritis and daily intake of β-cryptoxanthin has been epidemiologically shown. In this study, we investigated the effects of β-cryptoxanthin on the metabolism of cartilage extracellular matrix in vivo and in vitro. Oral administration of β-cryptoxanthin (0.1–1 mg/kg) to antigen-induced arthritic rats suppressed the loss of glycosaminoglycans in articular cartilage, which is accompanied by the interference of aggrecanase-mediated degradation of aggrecan. Inhibition of the interleukin 1α (IL-1α)-induced aggrecan degradation by β-cryptoxanthin was also observed with porcine articular cartilage explants in culture. β-Cryptoxanthin (1–10 μM) dose-dependently down-regulated the IL-1α-induced gene expression of aggrecanase 1 (ADAMTS-4) and aggrecanase 2 (ADAMTS-5) in cultured human chondrocytes. Moreover, β-cryptoxanthin was found to augment the gene expression of aggrecan core protein in chondrocytes. These results provide novel evidence that β-cryptoxanthin exerts anti-arthritic actions and suggest that β-cryptoxanthin may be useful in blocking the progression of rheumatoid arthritis and osteoarthritis.

Item Type: Article
Additional Information: © 2016. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
SGUL Research Institute / Research Centre: Academic Structure > Infection and Immunity Research Institute (INII)
Journal or Publication Title: Biochemical and Biophysical Research Communications
ISSN: 0006-291X
Dates:
DateEvent
27 May 2016Published
24 May 2016Accepted
Publisher License: Creative Commons: Attribution-Noncommercial-No Derivative Works 4.0
Projects:
Project IDFunderFunder ID
UNSPECIFIEDArthritis Research UKhttp://dx.doi.org/10.13039/501100000341
AR40449National Institutes of Healthhttp://dx.doi.org/10.13039/100000002
URI: https://openaccess.sgul.ac.uk/id/eprint/107943
Publisher's version: https://doi.org/10.1016/j.bbrc.2016.05.126

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