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Effects of maternal geohelminth infections on allergy in early childhood.

Cooper, PJ; Chico, ME; Amorim, LD; Sandoval, C; Vaca, M; Strina, A; Campos, AC; Rodrigues, LC; Barreto, ML; Strachan, DP (2016) Effects of maternal geohelminth infections on allergy in early childhood. Journal of Allergy and Clinical Immunology, 137 (3). 899-906.e2. ISSN 1097-6825 https://doi.org/10.1016/j.jaci.2015.07.044
SGUL Authors: Strachan, David Peter Cooper, Philip John

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Abstract

BACKGROUND: Maternal geohelminth infections during pregnancy may protect against allergy development in childhood. OBJECTIVE: We sought to investigate the effect of maternal geohelminths on the development of eczema, wheeze, and atopy during the first 3 years of life. METHODS: A cohort of 2404 neonates was followed to 3 years of age in a rural district in coastal Ecuador. Data on wheeze and eczema were collected by means of questionnaire and physical examination at 13, 24, and 36 months of age. Atopy was measured based on skin prick test (SPT) reactivity to 9 allergens at 36 months. Maternal stool samples were examined for geohelminths by microscopy. Data on potential confounders was collected after birth by questionnaire. RESULTS: Geohelminths were observed in 45.9% of mothers. Eczema and wheeze were reported for 17.7% and 25.9%, respectively, of 2069 (86.1%) children with complete follow-up to 3 years, and allergen SPT reactivity to any allergen was present in 17.2% and to house dust mite in 8.7%. Maternal geohelminth infections were not significantly associated with eczema (adjusted odds ratio [OR], 1.26; 95% CI, 0.98-1.61), wheeze (adjusted OR, 1.02; 95% CI, 0.82-1.27), and SPT reactivity to any allergen (adjusted OR, 0.79; 95% CI, 0.61-1.01). In subgroup analyses maternal geohelminths were associated with a significantly reduced risk of SPT reactivity to mite and other perennial allergens, and maternal ascariasis was associated with an increased risk of eczema and reduced risk of SPT reactivity to all allergens. CONCLUSION: Our data do not support a protective effect of maternal infections with geohelminth parasites during pregnancy against the development of eczema and wheeze in early childhood, although there was evidence in subgroup analyses for a reduction in SPT reactivity to house dust mites and perennial allergens.

Item Type: Article
Additional Information: © 2015 The Authors. Published by Elsevier Inc. on behalf of the American Academy of Allergy, Asthma & Immunology. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
Keywords: Geohelminths, atopy, early childhood, eczema, maternal infections, wheeze, Allergens, Animals, Child, Preschool, Eczema, Female, Follow-Up Studies, Helminthiasis, Humans, Hypersensitivity, Infant, Infant, Newborn, Male, Maternal Exposure, Odds Ratio, Patient Outcome Assessment, Pregnancy, Pyroglyphidae, Respiratory Sounds, Risk Factors, Animals, Humans, Pyroglyphidae, Helminthiasis, Eczema, Hypersensitivity, Respiratory Sounds, Allergens, Odds Ratio, Risk Factors, Follow-Up Studies, Maternal Exposure, Pregnancy, Child, Preschool, Infant, Infant, Newborn, Female, Male, Patient Outcome Assessment, Geohelminths, maternal infections, atopy, wheeze, eczema, early childhood, Geohelminths, atopy, early childhood, eczema, maternal infections, wheeze, Allergens, Animals, Child, Preschool, Eczema, Female, Follow-Up Studies, Helminthiasis, Humans, Hypersensitivity, Infant, Infant, Newborn, Male, Maternal Exposure, Odds Ratio, Patient Outcome Assessment, Pregnancy, Pyroglyphidae, Respiratory Sounds, Risk Factors, Allergy, 1107 Immunology
SGUL Research Institute / Research Centre: Academic Structure > Infection and Immunity Research Institute (INII)
Academic Structure > Population Health Research Institute (INPH)
Journal or Publication Title: Journal of Allergy and Clinical Immunology
ISSN: 1097-6825
Language: eng
Dates:
DateEvent
1 March 2016Published
26 September 2015Published Online
14 July 2015Accepted
Publisher License: Creative Commons: Attribution 4.0
Projects:
Project IDFunderFunder ID
088862Wellcome Trusthttp://dx.doi.org/10.13039/100004440
088862/Z/09/ZWellcome Trusthttp://dx.doi.org/10.13039/100004440
100714Wellcome Trusthttp://dx.doi.org/10.13039/100004440
PubMed ID: 26395817
Web of Science ID: WOS:000371897500034
Go to PubMed abstract
URI: https://openaccess.sgul.ac.uk/id/eprint/107773
Publisher's version: https://doi.org/10.1016/j.jaci.2015.07.044

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