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Multi-ancestry genome-wide association study of 21,000 cases and 95,000 controls identifies new risk loci for atopic dermatitis

Paternoster, L; Standl, M; Waage, J; Baurecht, H; Hotze, M; Strachan, DP; Curtin, JA; Bonnelykke, K; Tian, C; Takahashi, A; et al. Paternoster, L; Standl, M; Waage, J; Baurecht, H; Hotze, M; Strachan, DP; Curtin, JA; Bonnelykke, K; Tian, C; Takahashi, A; Esparza-Gordillo, J; Alves, AC; Thyssen, JP; den Dekker, HT; Ferreira, MA; Altmaier, E; Sleiman, PMA; Xiao, FL; Gonzalez, JR; Marenholz, I; Kalb, B; Pino-Yanes, M; Xu, C-J; Carstensen, L; Groen-Blokhuis, MM; Venturini, C; Pennell, CE; Barton, SJ; Levin, AM; Curjuric, I; Bustamante, M; Kreiner-Moller, E; Lockett, GA; Bacelis, J; Bunyavanich, S; Myers, RA; Matanovic, A; Kumar, A; Tung, JY; Hirota, T; Kubo, M; McArdle, WL; Henderson, AJ; Kemp, JP; Zheng, J; Smith, GD; Rueschendorf, F; Bauerfeind, A; Lee-Kirsch, MA; Arnold, A; Homuth, G; Schmidt, CO; Mangold, E; Cichon, S; Keil, T; Rodriguez, E; Peters, A; Franke, A; Lieb, W; Novak, N; Foelster-Holst, R; Horikoshi, M; Pekkanen, J; Sebert, S; Husemoen, LL; Grarup, N; De Jongste, JC; Rivadeneira, F; Hofman, A; Jaddoe, VWV; Pasmans, SGMA; Elbert, NJ; Uitterlinden, AG; Marks, GB; Thompson, PJ; Matheson, MC; Robertson, CF; Ried, JS; Li, J; Zuo, XB; Zheng, XD; Yin, XY; Sun, LD; McAleer, MA; O'Regan, GM; Fahy, CMR; Campbell, LE; Macek, M; Kurek, M; Hu, D; Eng, C; Postma, DS; Feenstra, B; Geller, F; Hottenga, JJ; Middeldorp, CM; Hysi, P; Bataille, V; Spector, T; Tiesler, CMT; Thiering, E; Pahukasahasram, B; Yang, JJ; Imboden, M; Huntsman, S; Vilor-Tejedor, N; Relton, CL; Myhre, R; Nystad, W; Custovic, A; Weiss, ST; Meyers, DA; Soederhaell, C; Melen, E; Ober, C; Raby, BA; Simpson, A; Jacobsson, B; Holloway, JW; Bisgaard, H; Sunyer, J; Probst-Hensch, NM; Williams, LK; Godfrey, KM; Wang, CA; Boomsma, DI; Melbye, M; Koppelman, GH; Jarvis, D; McLean, WHI; Irvine, AD; Zhang, XJ; Hakonarson, H; Gieger-, C; Burchard, EG; Martin, NG; Duijts, L; Linneberg, A; Jarvelin, M-R; Noethen, MM; Lau, S; Huebner, N; Lee, Y-A; Tamari, M; Hinds, DA; Glass, D; Brown, SJ; Heinrich, J; Evans, DM; Weidinger, S; AAGC, AAGC; Epidemio, EGL (2015) Multi-ancestry genome-wide association study of 21,000 cases and 95,000 controls identifies new risk loci for atopic dermatitis. Nature Genetics, 47 (12). pp. 1449-1456. https://doi.org/10.1038/ng.3424
SGUL Authors: Strachan, David Peter

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Abstract

Genetic association studies have identified 21 loci associated with atopic dermatitis risk predominantly in populations of European ancestry. To identify further susceptibility loci for this common, complex skin disease, we performed a meta-analysis of >15 million genetic variants in 21,399 cases and 95,464 controls from populations of European, African, Japanese and Latino ancestry, followed by replication in 32,059 cases and 228,628 controls from 18 studies. We identified ten new risk loci, bringing the total number of known atopic dermatitis risk loci to 31 (with new secondary signals at four of these loci). Notably, the new loci include candidate genes with roles in the regulation of innate host defenses and T cell function, underscoring the important contribution of (auto)immune mechanisms to atopic dermatitis pathogenesis.

Item Type: Article
Additional Information: © 2015 Nature America, Inc. All rights reserved
Keywords: Developmental Biology, 11 Medical And Health Sciences, 06 Biological Sciences
SGUL Research Institute / Research Centre: Academic Structure > Population Health Research Institute (INPH)
Journal or Publication Title: Nature Genetics
Dates:
DateEvent
19 October 2015Published
Publisher License: Publisher's own licence
Web of Science ID: WOS:000365813200017
URI: https://openaccess.sgul.ac.uk/id/eprint/107705
Publisher's version: https://doi.org/10.1038/ng.3424

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