SORA

Advancing, promoting and sharing knowledge of health through excellence in teaching, clinical practice and research into the prevention and treatment of illness

A Systematic Review Investigating the Presence of Inflammatory Synovitis in Hip and Knee Joint Replacement Surgery.

Hosny, S; Strambi, F; Sofat, N; Field, R (2015) A Systematic Review Investigating the Presence of Inflammatory Synovitis in Hip and Knee Joint Replacement Surgery. Arthritis, 2015. p. 729410. ISSN 2090-1984 https://doi.org/10.1155/2015/729410
SGUL Authors: Sofat, Nidhi

[img]
Preview
PDF Published Version
Available under License Creative Commons Attribution.

Download (614kB) | Preview

Abstract

Synovial tissue can display an inflammatory response in the presence of OA. There is increasing interest to better understand the role of inflammation in OA, particularly with regard to those who require joint replacement. A systematic review of inflammatory synovitis in OA of literature databases was undertaken from their inception until October 14, 2014. Independent critical appraisal of each study was undertaken using the CASP appraisal tool. From a total of sixty-six identified citations, twenty-three studies were deemed eligible for review. The studies presented moderate to strong methodological quality. Strong correlation was identified between histological and imaging synovitis severity. Correlation was weaker between clinical symptoms and imaging and/or histological synovitis severity. There was little consensus, with regard to expressed cytokines and chemokines at the different stages of OA disease progression. Few studies investigated the influence of inflammatory synovitis on the outcome of major joint replacement. Research into inflammatory synovitis in OA is an emerging field. Longitudinal studies applying proven imaging modalities, histological analysis, and longer follow-up are required in order to further define our understanding of the role of synovitis in the pathogenesis of OA and its effects on outcomes following major joint replacement.

Item Type: Article
Additional Information: Copyright © 2015 Sherif Hosny et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
SGUL Research Institute / Research Centre: Academic Structure > Infection and Immunity Research Institute (INII)
Journal or Publication Title: Arthritis
ISSN: 2090-1984
Language: eng
Dates:
DateEvent
18 October 2015Published
16 September 2016Accepted
Publisher License: Creative Commons: Attribution 3.0
PubMed ID: 26557388
Go to PubMed abstract
URI: https://openaccess.sgul.ac.uk/id/eprint/107578
Publisher's version: https://doi.org/10.1155/2015/729410

Actions (login required)

Edit Item Edit Item