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Uric Acid as a predictor of adverse maternal and perinatal outcomes in women hospitalized with preeclampsia.

Livingston, JR; Payne, B; Brown, M; Roberts, JM; Côté, AM; Magee, LA; von Dadelszen, P (2014) Uric Acid as a predictor of adverse maternal and perinatal outcomes in women hospitalized with preeclampsia. Journal of Obstetrics and Gynaecology Canada, 36 (10). pp. 870-877. ISSN 1701-2163 https://doi.org/10.1016/S1701-2163(15)30435-7
SGUL Authors: von Dadelszen, Peter

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Abstract

OBJECTIVE: Elevated serum uric acid is commonly observed in women with preeclampsia, but its utility in predicting adverse outcomes has recently been disputed. Our goal was to analyze data from a large cohort of women with preeclampsia to determine the utility of serum uric acid in predicting adverse maternal and perinatal outcomes. METHODS: Data were obtained from an ongoing international prospective study of women admitted to hospital with preeclampsia (Pre-eclampsia Integrated Estimate of RiSk). Univariate logistic regression was used to determine the relationship between serum uric acid concentration (both absolute and gestational-age corrected [Z score]) and adverse outcomes (maternal and perinatal). Analyses were conducted to compare cohorts of women with preeclampsia as defined by hypertension and proteinuria versus hypertension and hyperuricemia. RESULTS: Uric acid Z score was associated with adverse perinatal outcome (OR 1.5; 95% CI 1.4 to 1.7) and had a point estimate > 0.7 (area under the curve receiver operating characteristic 0.72; 95% CI 0.69 to 0.74). Serum uric acid concentration also showed a significant association with adverse maternal outcomes, but the point estimate was < 0.7. No significant differences were observed between groups in which preeclampsia was defined by hypertension and proteinuria and by hypertension and hyperuricemia. CONCLUSION: In women admitted to hospital with preeclampsia, the serum uric acid concentration, corrected for gestational age via a Z score, is clinically useful in predicting adverse perinatal outcomes but not maternal outcomes.

Item Type: Article
Additional Information: © 2014 Society of Obstetricians and Gynaecologists of Canada. Published by Elsevier Inc. All rights reserved. Made available with permission from the publisher. Contact publisher for any further re-use.
Keywords: preeclampsia, pregnancy outcome, risk assessment, uric acid, Adult, Cohort Studies, Female, Humans, Pre-Eclampsia, Predictive Value of Tests, Pregnancy, Pregnancy Outcome, Risk Factors, Uric Acid, Humans, Pre-Eclampsia, Uric Acid, Pregnancy Outcome, Risk Factors, Cohort Studies, Predictive Value of Tests, Pregnancy, Adult, Female, 1114 Paediatrics And Reproductive Medicine
SGUL Research Institute / Research Centre: Academic Structure > Molecular and Clinical Sciences Research Institute (MCS)
Journal or Publication Title: Journal of Obstetrics and Gynaecology Canada
ISSN: 1701-2163
Language: eng
Dates:
DateEvent
1 October 2014Published
Publisher License: Publisher's own licence
Projects:
Project IDFunderFunder ID
UNSPECIFIEDCanadian Institutes of Health Researchhttp://dx.doi.org/10.13039/501100000024
PubMed ID: 25375299
Go to PubMed abstract
URI: https://openaccess.sgul.ac.uk/id/eprint/107516
Publisher's version: https://doi.org/10.1016/S1701-2163(15)30435-7

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