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Norovirus Infection and Disease in an Ecuadorian Birth Cohort: Association of Certain Norovirus Genotypes With Host FUT2 Secretor Status.

Lopman, BA; Trivedi, T; Vicuña, Y; Costantini, V; Collins, N; Gregoricus, N; Parashar, U; Sandoval, C; Broncano, N; Vaca, M; et al. Lopman, BA; Trivedi, T; Vicuña, Y; Costantini, V; Collins, N; Gregoricus, N; Parashar, U; Sandoval, C; Broncano, N; Vaca, M; Chico, ME; Vinjé, J; Cooper, PJ (2015) Norovirus Infection and Disease in an Ecuadorian Birth Cohort: Association of Certain Norovirus Genotypes With Host FUT2 Secretor Status. J Infect Dis, 211 (11). pp. 1813-1821. ISSN 1537-6613 https://doi.org/10.1093/infdis/jiu672
SGUL Authors: Cooper, Philip John

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Abstract

BACKGROUND: Although norovirus is the most common cause of gastroenteritis, there are few data on the community incidence of infection/disease or the patterns of acquired immunity or innate resistance to norovirus. METHODS: We followed a community-based birth cohort of 194 children in Ecuador with the aim to estimate (1) the incidence of norovirus gastroenteritis from birth to age 3 years, (2) the protective effect of norovirus infection against subsequent infection/disease, and (3) the association of infection and disease with FUT2 secretor status. RESULTS: Over the 3-year period, we detected a mean of 2.26 diarrheal episodes per child (range, 0-12 episodes). Norovirus was detected in 260 samples (18%) but was not found more frequently in diarrheal samples (79 of 438 [18%]), compared with diarrhea-free samples (181 of 1016 [18%]; P = .919). A total of 66% of children had at least 1 norovirus infection during the first 3 years of life, and 40% of children had 2 infections. Previous norovirus infections were not associated with the risk of subsequent infection. All genogroup II, genotype 4 (GII.4) infections were among secretor-positive children (P < .001), but higher rates of non-GII.4 infections were found in secretor-negative children (relative risk, 0.56; P = .029). CONCLUSIONS: GII.4 infections were uniquely detected in secretor-positive children, while non-GII.4 infections were more often found in secretor-negative children.

Item Type: Article
Additional Information: © The Author 2014. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/ by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
Keywords: cohort study, histo-blood group antigen, immunity, incidence, norovirus, norovirus, immunity, histo-blood group antigen, cohort study, incidence, Microbiology, 11 Medical And Health Sciences, 06 Biological Sciences
SGUL Research Institute / Research Centre: Academic Structure > Infection and Immunity Research Institute (INII)
Journal or Publication Title: J Infect Dis
ISSN: 1537-6613
Language: eng
Dates:
DateEvent
1 June 2015Published
Publisher License: Creative Commons: Attribution 4.0
Projects:
Project IDFunderFunder ID
088862/Z/09/ZWellcome Trusthttp://dx.doi.org/10.13039/100004440
074679/Z/04/ZWellcome Trusthttp://dx.doi.org/10.13039/100004440
PubMed ID: 25505295
Web of Science ID: WOS:000355675100016
Go to PubMed abstract
URI: https://openaccess.sgul.ac.uk/id/eprint/107447
Publisher's version: https://doi.org/10.1093/infdis/jiu672

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