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Melanocytes are selectively vulnerable to UVA-mediated bystander oxidative signaling.

Redmond, RW; Rajadurai, A; Udayakumar, D; Sviderskaya, EV; Tsao, H (2014) Melanocytes are selectively vulnerable to UVA-mediated bystander oxidative signaling. Journal of Investigative Dermatology, 134 (4). pp. 1083-1090. ISSN 1523-1747 https://doi.org/10.1038/jid.2013.479
SGUL Authors: Sviderskaya, Elena Vladimirovna

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Abstract

Long-wave UVA is the major component of terrestrial UV radiation and is also the predominant constituent of indoor sunlamps, both of which have been shown to increase cutaneous melanoma risk. Using a two-chamber model, we show that UVA-exposed target cells induce intercellular oxidative signaling to non-irradiated bystander cells. This UVA-mediated bystander stress is observed between all three cutaneous cell types (i.e., keratinocytes, melanocytes, and fibroblasts). Significantly, melanocytes appear to be more resistant to direct UVA effects compared with keratinocytes and fibroblasts, although melanocytes are also more susceptible to bystander oxidative signaling. The extensive intercellular flux of oxidative species has not been previously appreciated and could possibly contribute to the observed cancer risk associated with prolonged UVA exposure.

Item Type: Article
Additional Information: Author’s manuscript is made available for academic research only, and cannot be used for commercial purposes without prior permission of the copyright holders. Made available here with permission from the publisher.
Keywords: Animals, Bystander Effect, Cell Survival, Cells, Cultured, Coculture Techniques, Comet Assay, Fibroblasts, Humans, Keratinocytes, Melanocytes, Melanoma, Mice, Mice, Inbred C57BL, Microscopy, Fluorescence, Neoplasms, Radiation-Induced, Oxidative Stress, Oxygen, Reactive Oxygen Species, Signal Transduction, Skin Neoplasms, Ultraviolet Rays, Dermatology & Venereal Diseases, 1103 Clinical Sciences, 1112 Oncology And Carcinogenesis
SGUL Research Institute / Research Centre: Academic Structure > Molecular and Clinical Sciences Research Institute (MCS) > Cell Sciences (INCCCS)
Journal or Publication Title: Journal of Investigative Dermatology
ISSN: 1523-1747
Language: eng
Dates:
DateEvent
April 2014Published
PubMed ID: 24335898
Go to PubMed abstract
URI: https://openaccess.sgul.ac.uk/id/eprint/107309
Publisher's version: https://doi.org/10.1038/jid.2013.479

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