SORA

Advancing, promoting and sharing knowledge of health through excellence in teaching, clinical practice and research into the prevention and treatment of illness

Sarcopenic obesity and risk of cardiovascular disease and mortality: a population-based cohort study of older men.

Atkins, JL; Whincup, PH; Morris, RW; Lennon, LT; Papacosta, O; Wannamethee, SG (2014) Sarcopenic obesity and risk of cardiovascular disease and mortality: a population-based cohort study of older men. Journal of the American Geriatrics Society, 62 (2). pp. 253-260. ISSN 1532-5415 https://doi.org/10.1111/jgs.12652
SGUL Authors: Whincup, Peter Hynes

[img]
Preview
["document_typename_application/pdf; charset=binary" not defined] Published Version
Download (303kB) | Preview

Abstract

OBJECTIVES: To examine associations between sarcopenia, obesity, and sarcopenic obesity and risk of cardiovascular disease (CVD) and all-cause mortality in older men. DESIGN: Prospective cohort study. SETTING: British Regional Heart Study. PARTICIPANTS: Men aged 60-79 years (n = 4,252). MEASUREMENTS: Baseline waist circumference (WC) and midarm muscle circumference (MAMC) measurements were used to classify participants into four groups: sarcopenic, obese, sarcopenic obese, or optimal WC and MAMC. The cohort was followed for a mean of 11.3 years for CVD and all-cause mortality. Cox regression analyses assessed associations between sarcopenic obesity groups and all-cause mortality, CVD mortality, CVD events, and coronary heart disease (CHD) events. RESULTS: There were 1,314 deaths, 518 CVD deaths, 852 CVD events, and 458 CHD events during follow-up. All-cause mortality risk was significantly greater in sarcopenic (HR = 1.41, 95% CI = 1.22-1.63) and obese (HR = 1.21, 95% CI = 1.03-1.42) men than in the optimal reference group, with the highest risk in sarcopenic obese (HR = 1.72, 95% CI = 1.35-2.18), after adjustment for lifestyle characteristics. Risk of CVD mortality was significantly greater in sarcopenic and obese but not sarcopenic obese men. No association was seen between sarcopenic obesity groups and CHD or CVD events. CONCLUSION: Sarcopenia and central adiposity were associated with greater cardiovascular mortality and all-cause mortality. Sarcopenic obese men had the highest risk of all-cause mortality but not CVD mortality. Efforts to promote healthy aging should focus on preventing obesity and maintaining muscle mass.

Item Type: Article
Additional Information: © 2014, Copyright the Authors. Journal compilation © 2014, The American Geriatrics Society. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Keywords: cardiovascular disease, mortality, muscle mass, obesity, sarcopenia, Aged, Body Composition, Body Mass Index, Cardiovascular Diseases, Cause of Death, Cohort Studies, Forecasting, Great Britain, Humans, Male, Middle Aged, Obesity, Population Surveillance, Prospective Studies, Risk Assessment, Risk Factors, Geriatrics, 11 Medical And Health Sciences
SGUL Research Institute / Research Centre: Academic Structure > Population Health Research Institute (INPH)
Journal or Publication Title: Journal of the American Geriatrics Society
ISSN: 1532-5415
Language: eng
Dates:
DateEvent
February 2014Published
PubMed ID: 24428349
Go to PubMed abstract
URI: https://openaccess.sgul.ac.uk/id/eprint/107266
Publisher's version: https://doi.org/10.1111/jgs.12652

Actions (login required)

Edit Item Edit Item