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Multivariable regression analysis of febrile neutropenia occurrence in early breast cancer patients receiving chemotherapy assessing patient-related, chemotherapy-related and genetic risk factors.

Pfeil, AM; Vulsteke, C; Paridaens, R; Dieudonné, AS; Pettengell, R; Hatse, S; Neven, P; Lambrechts, D; Szucs, TD; Schwenkglenks, M; et al. Pfeil, AM; Vulsteke, C; Paridaens, R; Dieudonné, AS; Pettengell, R; Hatse, S; Neven, P; Lambrechts, D; Szucs, TD; Schwenkglenks, M; Wildiers, H (2014) Multivariable regression analysis of febrile neutropenia occurrence in early breast cancer patients receiving chemotherapy assessing patient-related, chemotherapy-related and genetic risk factors. BMC Cancer, 14 (201). ISSN 1471-2407 https://doi.org/10.1186/1471-2407-14-201
SGUL Authors: Pettengell, Ruth

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Abstract

BACKGROUND: Febrile neutropenia (FN) is common in breast cancer patients undergoing chemotherapy. Risk factors for FN have been reported, but risk models that include genetic variability have yet to be described. This study aimed to evaluate the predictive value of patient-related, chemotherapy-related, and genetic risk factors. METHODS: Data from consecutive breast cancer patients receiving chemotherapy with 4-6 cycles of fluorouracil, epirubicin, and cyclophosphamide (FEC) or three cycles of FEC and docetaxel were retrospectively recorded. Multivariable logistic regression was carried out to assess risk of FN during FEC chemotherapy cycles. RESULTS: Overall, 166 (16.7%) out of 994 patients developed FN. Significant risk factors for FN in any cycle and the first cycle were lower platelet count (OR = 0.78 [0.65; 0.93]) and haemoglobin (OR = 0.81 [0.67; 0.98]) and homozygous carriers of the rs4148350 variant T-allele (OR = 6.7 [1.04; 43.17]) in MRP1. Other significant factors for FN in any cycle were higher alanine aminotransferase (OR = 1.02 [1.01; 1.03]), carriers of the rs246221 variant C-allele (OR = 2.0 [1.03; 3.86]) in MRP1 and the rs351855 variant C-allele (OR = 2.48 [1.13; 5.44]) in FGFR4. Lower height (OR = 0.62 [0.41; 0.92]) increased risk of FN in the first cycle. CONCLUSIONS: Both established clinical risk factors and genetic factors predicted FN in breast cancer patients. Prediction was improved by adding genetic information but overall remained limited. Internal validity was satisfactory. Further independent validation is required to confirm these findings.

Item Type: Article
Additional Information: © 2014 Pfeil et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited.
Keywords: Adult, Antineoplastic Agents, Breast Neoplasms, Early Diagnosis, Febrile Neutropenia, Female, Genetic Predisposition to Disease, Humans, Middle Aged, Polymorphism, Single Nucleotide, Regression Analysis, Retrospective Studies, Risk Factors, Multivariable analysis, Chemotherapy, Breast neoplasms, Genetics, Single nucleotide polymorphism, Science & Technology, Life Sciences & Biomedicine, Oncology, ANTHRACYCLINE-INDUCED CARDIOTOXICITY, CLINICAL-PRACTICE GUIDELINE, NON-HODGKIN-LYMPHOMA, GROWTH-FACTORS, SOLID TUMORS, POLYMORPHISMS, MODEL, MALIGNANCIES, ASSOCIATION, MANAGEMENT, Oncology & Carcinogenesis, 1112 Oncology And Carcinogenesis
SGUL Research Institute / Research Centre: Academic Structure > Institute of Medical & Biomedical Education (IMBE)
Academic Structure > Institute of Medical & Biomedical Education (IMBE) > Centre for Clinical Education (INMECE )
Journal or Publication Title: BMC Cancer
ISSN: 1471-2407
Language: eng
Dates:
DateEvent
19 March 2014Published
PubMed ID: 24641830
Web of Science ID: WOS:000333422900001
Go to PubMed abstract
URI: https://openaccess.sgul.ac.uk/id/eprint/107229
Publisher's version: https://doi.org/10.1186/1471-2407-14-201

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