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Combined Inflammatory and Metabolic Defects Reflected by Reduced Serum Protein Levels in Patients with Buruli Ulcer Disease

Phillips, RO; Sarfo, FS; Landier, J; Oldenburg, R; Frimpong, M; Wansbrough-Jones, M; Abass, K; Thompson, W; Forson, M; Fontanet, A; et al. Phillips, RO; Sarfo, FS; Landier, J; Oldenburg, R; Frimpong, M; Wansbrough-Jones, M; Abass, K; Thompson, W; Forson, M; Fontanet, A; Niang, F; Demangel, C (2014) Combined Inflammatory and Metabolic Defects Reflected by Reduced Serum Protein Levels in Patients with Buruli Ulcer Disease. PLOS NEGLECTED TROPICAL DISEASES, 8 (4). e2786 (1)- e2786 (11). ISSN 1935-2735 https://doi.org/10.1371/journal.pntd.0002786
SGUL Authors: Wansbrough-Jones, Mark Harding Phillips, Richard Frimpong, Michael

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Abstract

Buruli ulcer is a skin disease caused by Mycobacterium ulcerans that is spreading in tropical countries, with major public health and economic implications in West Africa. Multi-analyte profiling of serum proteins in patients and endemic controls revealed that Buruli ulcer disease down-regulates the circulating levels of a large array of inflammatory mediators, without impacting on the leukocyte composition of peripheral blood. Notably, several proteins contributing to acute phase reaction, lipid metabolism, coagulation and tissue remodelling were also impacted. Their down-regulation was selective and persisted after the elimination of bacteria with antibiotic therapy. It involved proteins with various functions and origins, suggesting that M. ulcerans infection causes global and chronic defects in the host’s protein metabolism. Accordingly, patients had reduced levels of total serum proteins and blood urea, in the absence of signs of malnutrition, or functional failure of liver or kidney. Interestingly, slow healers had deeper metabolic and coagulation defects at the start of antibiotic therapy. In addition to providing novel insight into Buruli ulcer pathogenesis, our study therefore identifies a unique proteomic signature for this disease.

Item Type: Article
Additional Information: Copyright: 2014 Phillips et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Keywords: Science & Technology, Life Sciences & Biomedicine, Infectious Diseases, Parasitology, Tropical Medicine, MYCOBACTERIUM-ULCERANS, MYCOLACTONE DIFFUSES, CYTOKINE PRODUCTION, PERIPHERAL-BLOOD, IN-VIVO, TOXIN, STREPTOMYCIN, INFECTION, RIFAMPIN, COMBINATION, Tropical Medicine, Biological Sciences, Medical And Health Sciences
SGUL Research Institute / Research Centre: Academic Structure > Infection and Immunity Research Institute (INII)
Journal or Publication Title: PLOS NEGLECTED TROPICAL DISEASES
ISSN: 1935-2735
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Dates:
DateEvent
10 April 2014Published
Web of Science ID: WOS:000335342400057
URI: https://openaccess.sgul.ac.uk/id/eprint/107072
Publisher's version: https://doi.org/10.1371/journal.pntd.0002786

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