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The Seroepidemiology of Haemophilus influenzae Type B Prior to Introduction of an Immunization Programme in Kathmandu, Nepal.

Marshall, AS; Barker, CI; Pulickal, AS; Kibwana, E; Gautam, SC; Clutterbuck, EA; Thorson, SM; Shrestha, S; Adhikari, N; Pollard, AJ; et al. Marshall, AS; Barker, CI; Pulickal, AS; Kibwana, E; Gautam, SC; Clutterbuck, EA; Thorson, SM; Shrestha, S; Adhikari, N; Pollard, AJ; Kelly, DF (2014) The Seroepidemiology of Haemophilus influenzae Type B Prior to Introduction of an Immunization Programme in Kathmandu, Nepal. PLoS One, 9 (1). e85055 -r85055 (4). https://doi.org/10.1371/journal.pone.0085055
SGUL Authors: Barker, Charlotte Ida Sophia

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Abstract

Haemophilus influenzae type b (Hib) is now recognized as an important pathogen in Asia. To evaluate disease susceptibility, and as a marker of Hib transmission before routine immunization was introduced in Kathmandu, 71 participants aged 7 months-77 years were recruited and 15 cord blood samples were collected for analysis of anti-polyribosylribitol phosphate antibody levels by enzyme-linked immunosorbent assay. Only 20% of children under 5 years old had levels considered protective (>0.15 µg/ml), rising to 83% of 15-54 year-olds. Prior to introduction of Hib vaccine in Kathmandu, the majority of young children were susceptible to disease.

Item Type: Article
Additional Information: PMCID: PMC3898912
SGUL Research Institute / Research Centre: Academic Structure > Infection and Immunity Research Institute (INII)
Journal or Publication Title: PLoS One
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Dates:
DateEvent
22 January 2014Published
PubMed ID: 24465475
Web of Science ID: 24465475
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URI: https://openaccess.sgul.ac.uk/id/eprint/104773
Publisher's version: https://doi.org/10.1371/journal.pone.0085055

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