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Multi-center transferability of a breath-hold T2 technique for myocardial iron assessment.

He, T; Kirk, P; Firmin, DN; Lam, WM; Chu, WC; Au, WY; Chan, GC; Tan, RS; Ng, I; Biceroglu, S; et al. He, T; Kirk, P; Firmin, DN; Lam, WM; Chu, WC; Au, WY; Chan, GC; Tan, RS; Ng, I; Biceroglu, S; Aydinok, Y; Fogel, MA; Cohen, AR; Pennell, DJ (2008) Multi-center transferability of a breath-hold T2 technique for myocardial iron assessment. Journal of Cardiovascular Magnetic Resonance, 10. pp. 1-4. ISSN 1097-6647 https://doi.org/10.1186/1532-429X-10-11
SGUL Authors: He, Taigang

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Abstract

Background: Cardiac iron overload is the leading cause of death in thalassemia major and is usually assessed using myocardial T2* measurements. Recently a cardiovascular magnetic resonance (CMR) breath-hold T2 sequence has been developed as a possible alternative. This cardiac T2 technique has good interstudy reproducibility, but its transferability to different centres has not yet been investigated. Methods and Results: The breath-hold black blood spin echo T2 sequence was installed and validated on 1.5T Siemens MR scanners at 4 different centres across the world. Using this sequence, 5–10 thalassemia patients from each centre were scanned twice locally within a week for local interstudy reproducibility (n = 34) and all were rescanned within one month at the standardization centre in London (intersite reproducibility). The local interstudy reproducibility (coefficient of variance) and mean difference were 4.4% and -0.06 ms. The intersite reproducibility and mean difference between scanners were 5.2% and -0.07 ms. Conclusion: The breath-hold myocardial T2 technique is transferable between Siemens scanners with good intersite and local interstudy reproducibility. This technique may have value in the diagnosis and management of patients with iron overload conditions such as thalassemia.

Item Type: Article
Additional Information: PubMed ID: 18291040. © 2008 He et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Keywords: Adult, Hong Kong, Humans, Iron, London, Magnetic Resonance Imaging, Myocardium, Observer Variation, Philadelphia, Predictive Value of Tests, Reproducibility of Results, Respiration, Singapore, Turkey, beta-Thalassemia, Science & Technology, Life Sciences & Biomedicine, Cardiac & Cardiovascular Systems, Radiology, Nuclear Medicine & Medical Imaging, Cardiovascular System & Cardiology, CARDIOVASCULAR MAGNETIC-RESONANCE, THALASSEMIA MAJOR, BETA-THALASSEMIA, TISSUE IRON, DEFEROXAMINE, DEFERIPRONE, T2-ASTERISK-MEASUREMENTS, DESFERRIOXAMINE, REPRODUCIBILITY, CARDIOMYOPATHY
SGUL Research Institute / Research Centre: Academic Structure > Molecular and Clinical Sciences Research Institute (MCS)
Academic Structure > Molecular and Clinical Sciences Research Institute (MCS) > Cardiac (INCCCA)
Journal or Publication Title: Journal of Cardiovascular Magnetic Resonance
ISSN: 1097-6647
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Dates:
DateEvent
21 February 2008Published
Web of Science ID: WOS:000257206500001
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URI: https://openaccess.sgul.ac.uk/id/eprint/102153
Publisher's version: https://doi.org/10.1186/1532-429X-10-11

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