SORA

Advancing, promoting and sharing knowledge of health through excellence in teaching, clinical practice and research into the prevention and treatment of illness

Serum contents of endocannabinoids are correlated with blood pressure in depressed women.

Ho, WS; Hill, MN; Miller, GE; Gorzalka, BB; Hillard, CJ (2012) Serum contents of endocannabinoids are correlated with blood pressure in depressed women. LIPIDS IN HEALTH AND DISEASE, 11 (32). ISSN 1476-511X https://doi.org/10.1186/1476-511X-11-32
SGUL Authors: Ho, Wing Sze Vanessa

[img]
Preview
["document_typename_application/pdf; charset=binary" not defined] Published Version
Download (505kB) | Preview

Abstract

BACKGROUND: Depression is known to be a risk factor for cardiovascular diseases but the underlying mechanisms remain unclear. Since recent preclinical evidence suggests that endogenous agonists of cannabinoid receptors (endocannabinoids) are involved in both cardiovascular function and depression, we asked whether endocannabinoids correlated with either in humans. RESULTS: Resting blood pressure and serum content of endocannabinoids in ambulatory, medication-free, female volunteers with depression (n = 28) and their age- and ethnicity-matched controls (n = 27) were measured. In females with depression, both diastolic and mean arterial blood pressures were positively correlated with serum contents of the endocannabinoids, N-arachidonylethanolamine (anandamide) and 2-arachidonoylglycerol. There was no correlation between blood pressure and endocannabinoids in control subjects. Furthermore, depressed women had significantly higher systolic blood pressure than control subjects. A larger body mass index was also found in depressed women, however, it was not significantly correlated with serum endocannabinoid contents. CONCLUSIONS: This preliminary study raises the possibility that endocannabinoids play a role in blood pressure regulation in depressives with higher blood pressure, and suggests an interrelationship among endocannabinoids, depression and cardiovascular risk factors in women.

Item Type: Article
Additional Information: © 2012 Vanessa Ho et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Keywords: Science & Technology, Life Sciences & Biomedicine, Biochemistry & Molecular Biology, Depression, Systolic blood pressure, Diastolic blood pressure, Cardiovascular risk, Anandamide, 2-arachidonoylglycerol, ACUTE MYOCARDIAL-INFARCTION, PITUITARY-ADRENAL AXIS, ACID AMIDE HYDROLASE, BAROREFLEX SENSITIVITY, CANNABINOID RECEPTORS, MAJOR DEPRESSION, CB1 RECEPTORS, RISK-FACTORS, CNR1 GENE, Adult, Biological Markers, Blood Pressure, Cannabinoid Receptor Modulators, Case-Control Studies, Endocannabinoids, Humans, Female
SGUL Research Institute / Research Centre: Academic Structure > Institute of Medical & Biomedical Education (IMBE)
Academic Structure > Institute of Medical & Biomedical Education (IMBE) > Centre for Biomedical Education (INMEBE)
Journal or Publication Title: LIPIDS IN HEALTH AND DISEASE
ISSN: 1476-511X
Dates:
DateEvent
28 February 2012Published
Web of Science ID: WOS:000303204300001
Download EPMC Full text (PDF)
Download EPMC Full text (HTML)
URI: https://openaccess.sgul.ac.uk/id/eprint/101510
Publisher's version: https://doi.org/10.1186/1476-511X-11-32

Actions (login required)

Edit Item Edit Item