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Predicting the prevalence of chronic kidney disease in the English population: a cross-sectional study.

Kearns, B; Gallagher, H; de Lusignan, S (2013) Predicting the prevalence of chronic kidney disease in the English population: a cross-sectional study. BMC NEPHROLOGY, 14 (49). ISSN 1471-2369 https://doi.org/10.1186/1471-2369-14-49
SGUL Authors: De Lusignan, Simon

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Abstract

BACKGROUND: There is concern that not all cases of chronic kidney disease (CKD) are known to general practitioners, leading to an underestimate of its true prevalence. We carried out this study to develop a model to predict the prevalence of CKD using a large English primary care dataset which includes previously undiagnosed cases of CKD. METHODS: Cross-sectional analysis of data from the Quality Improvement in CKD trial, a representative sample of 743 935 adults in England aged 18 and over. We created multivariable logistic regression models to identify important predictive factors. RESULTS: A prevalence of 6.76% was recorded in our sample, compared to a national prevalence of 4.3%. Increasing age, female gender and cardiovascular disease were associated with a significantly increased prevalence of CKD (p < 0.001 for all). Age had a complex association with CKD. Cardiovascular disease was a stronger predictive factor in younger than in older patients. For example, hypertension has an odds ratio of 2.02 amongst patients above average and an odds ratio of 3.91 amongst patients below average age. CONCLUSION: In England many cases of CKD remain undiagnosed. It is possible to use the results of this study to identify areas with high levels of undiagnosed CKD and groups at particular risk of having CKD.

Item Type: Article
Additional Information: Copyright ©2013 Kearns et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Keywords: Cardiovascular Diseases, Comorbidity, Cross-Sectional Studies, Diabetes Mellitus, England, Female, Humans, Male, Prevalence, Prognosis, Proportional Hazards Models, Renal Insufficiency, Chronic, Risk Factors, Smoking, Science & Technology, Life Sciences & Biomedicine, Urology & Nephrology, UROLOGY & NEPHROLOGY, Chronic kidney disease, Renal disease, Prevalence, Statistical modelling, Association, CARDIOVASCULAR-DISEASE, PRIMARY-CARE, MODEL SELECTION, RISK, VALIDATION, INFERENCE, ENGLAND, HEALTH, CKD
Journal or Publication Title: BMC NEPHROLOGY
ISSN: 1471-2369
Dates:
DateEvent
25 February 2013Published
Web of Science ID: WOS:000315799100001
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URI: https://openaccess.sgul.ac.uk/id/eprint/101448
Publisher's version: https://doi.org/10.1186/1471-2369-14-49

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