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The cyclin-dependent kinase inhibitor p57(Kip2) is epigenetically regulated in carboplatin resistance and results in collateral sensitivity to the CDK inhibitor seliciclib in ovarian cancer

Coley, HM; Safuwan, NA; Chivers, P; Papacharalbous, E; Giannopoulos, T; Butler-Manuel, S; Madhuri, K; Lovell, DP; Crook, T (2012) The cyclin-dependent kinase inhibitor p57(Kip2) is epigenetically regulated in carboplatin resistance and results in collateral sensitivity to the CDK inhibitor seliciclib in ovarian cancer. BRITISH JOURNAL OF CANCER, 106 (3). 482 - 489 (8). ISSN 0007-0920 https://doi.org/10.1038/bjc.2011.566
SGUL Authors: Lovell, David

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Item Type: Article
Additional Information: PubMed ID: 22233925
Keywords: Antineoplastic Agents, Carboplatin, Cell Line, Tumor, Cyclin-Dependent Kinase Inhibitor p27, DNA Methylation, Dose-Response Relationship, Drug, Down-Regulation, Drug Resistance, Neoplasm, Epigenesis, Genetic, Female, Humans, Ovarian Neoplasms, Purines, Science & Technology, Life Sciences & Biomedicine, Oncology, ovarian cancer, p57(Kip2), epigenetically silenced, carboplatin resistance, seliciclib, EXPRESSION, METHYLATION, P27(KIP1), SURVIVAL, AGENTS, CELLS, GENE, P53, D1, ovarian cancer, p57(Kip2), epigenetically silenced, carboplatin resistance, seliciclib
SGUL Research Institute / Research Centre: Academic Structure > Institute of Medical & Biomedical Education (IMBE)
Academic Structure > Institute of Medical & Biomedical Education (IMBE) > Centre for Biomedical Education (INMEBE)
Journal or Publication Title: BRITISH JOURNAL OF CANCER
ISSN: 0007-0920
Dates:
DateEvent
31 January 2012Published
Web of Science ID: WOS:000300302300009
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URI: https://openaccess.sgul.ac.uk/id/eprint/101427
Publisher's version: https://doi.org/10.1038/bjc.2011.566

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