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Survival of Staphylococcus aureus ST398 in the human nose after artificial inoculation.

Slingerland, BC; Tavakol, M; McCarthy, AJ; Lindsay, JA; Snijders, SV; Wagenaar, JA; van Belkum, A; Vos, MC; Verbrugh, HA; van Wamel, WJ (2012) Survival of Staphylococcus aureus ST398 in the human nose after artificial inoculation. PLOS ONE, 7 (11). e48896. ISSN 1932-6203 https://doi.org/10.1371/journal.pone.0048896
SGUL Authors: Lindsay, Jodi Anne

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Abstract

There is evidence that MRSA ST398 of animal origin is only capable of temporarily occupying the human nose, and it is therefore, often considered a poor human colonizer.We inoculated 16 healthy human volunteers with a mixture of the human MSSA strain 1036 (ST931, CC8) and the bovine MSSA strain 5062 (ST398, CC398), 7 weeks after a treatment with mupirocin and chlorhexidine-containing soap. Bacterial survival was studied by follow-up cultures over 21 days. The human strain 1036 was eliminated faster (median 14 days; range 2-21 days) than the bovine strain 5062 (median 21 days; range 7-21 days) but this difference was not significant (p = 0.065). The bacterial loads were significantly higher for the bovine strain on day 7 and day 21. 4/14 volunteers (28.6%) showed elimination of both strains within 21 days. Of the 10 remaining volunteers, 5 showed no differences in bacterial counts between both strains, and in the other 5 the ST398 strain far outnumbered the human S. aureus strain. Within the 21 days of follow-up, neither human strain 1036 nor bovine strain 5062 appeared to acquire or lose any mobile genetic elements. In conclusion, S. aureus ST398 strain 5062 is capable of adequately competing for a niche with a human strain and survives in the human nose for at least 21 days.

Item Type: Article
Additional Information: PMCID: PMC3498341 ©2012 Slingerland et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Keywords: Adult, Bacterial Load, Humans, Male, Middle Aged, Nose, Staphylococcus aureus
SGUL Research Institute / Research Centre: Academic Structure > Infection and Immunity Research Institute (INII)
Journal or Publication Title: PLOS ONE
ISSN: 1932-6203
Dates:
DateEvent
14 November 2012Published
PubMed ID: 23155425
Web of Science ID: 23155425
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URI: https://openaccess.sgul.ac.uk/id/eprint/100747
Publisher's version: https://doi.org/10.1371/journal.pone.0048896

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