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The minor groove-binding agent ELB-21 forms multiple interstrand and intrastrand covalent cross-links with duplex DNA and displays potent bactericidal activity against methicillin-resistant Staphylococcus aureus

Rosado, H; Rahman, KM; Feuerbaum, EA; Hinds, J; Thurston, DE; Taylor, PW (2011) The minor groove-binding agent ELB-21 forms multiple interstrand and intrastrand covalent cross-links with duplex DNA and displays potent bactericidal activity against methicillin-resistant Staphylococcus aureus. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 66 (5). 985 - 996 (12). ISSN 0305-7453 https://doi.org/10.1093/jac/dkr044
SGUL Authors: Hinds, Jason

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Item Type: Article
Additional Information: PubMed ID: 21393142
Keywords: Anti-Bacterial Agents, Benzodiazepines, Binding Sites, DNA, DNA Adducts, DNA Repair, Gene Expression Profiling, Gene Expression Regulation, Bacterial, Methicillin-Resistant Staphylococcus aureus, Microarray Analysis, Microbial Viability, Protein Binding, Pyrroles, Science & Technology, Life Sciences & Biomedicine, Infectious Diseases, Microbiology, Pharmacology & Pharmacy, antistaphylococcal activity, pyrrolobenzodiazepine dimer, DNA cross-linking, DNA adduct formation, MRSA, GRAM-POSITIVE BACTERIA, PYRROLOBENZODIAZEPINE DIMERS, VIRULENCE FACTORS, SOS RESPONSE, SEQUENCE, PHAGE, DESIGN, INHIBITION, REPRESSOR, SJG-136, antistaphylococcal activity, pyrrolobenzodiazepine dimer, DNA cross-linking, DNA adduct formation, MRSA
SGUL Research Institute / Research Centre: Academic Structure > Infection and Immunity Research Institute (INII)
Journal or Publication Title: JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
ISSN: 0305-7453
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Dates:
DateEvent
1 May 2011Published
Web of Science ID: WOS:000289584000005
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URI: http://openaccess.sgul.ac.uk/id/eprint/531
Publisher's version: https://doi.org/10.1093/jac/dkr044

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