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Impact of early life exposures to geohelminth infections on the development of vaccine immunity, allergic sensitization, and allergic inflammatory diseases in children living in tropical Ecuador: the ECUAVIDA birth cohort study.

Cooper, PJ; Chico, ME; Guadalupe, I; Sandoval, CA; Mitre, E; Platts-Mills, TA; Barreto, ML; Rodrigues, LC; Strachan, DP; Griffin, GE (2011) Impact of early life exposures to geohelminth infections on the development of vaccine immunity, allergic sensitization, and allergic inflammatory diseases in children living in tropical Ecuador: the ECUAVIDA birth cohort study. BMC INFECTIOUS DISEASES, 11 (184). ISSN 1471-2334 https://doi.org/10.1186/1471-2334-11-184
SGUL Authors: Griffin, George Edward Strachan, David Peter Cooper, Philip John

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Abstract

BACKGROUND: Geohelminth infections are highly prevalent infectious diseases of childhood in many regions of the Tropics, and are associated with significant morbidity especially among pre-school and school-age children. There is growing concern that geohelminth infections, particularly exposures occurring during early life in utero through maternal infections or during infancy, may affect vaccine immunogenicity in populations among whom these infections are endemic. Further, the low prevalence of allergic disease in the rural Tropics has been attributed to the immune modulatory effects of these infections and there is concern that widespread use of anthelmintic treatment in high-risk groups may be associated with an increase in the prevalence of allergic diseases. Because the most widely used vaccines are administered during the first year of life and the antecedents of allergic disease are considered to occur in early childhood, the present study has been designed to investigate the impact of early exposures to geohelminths on the development of protective immunity to vaccines, allergic sensitization, and allergic disease. METHODS/DESIGN: A cohort of 2,403 neonates followed up to 8 years of age. Primary exposures are infections with geohelminth parasites during the last trimester of pregnancy and the first 2 years of life. Primary study outcomes are the development of protective immunity to common childhood vaccines (i.e. rotavirus, Haemophilus influenzae type B, Hepatitis B, tetanus toxoid, and oral poliovirus type 3) during the first 5 years of life, the development of eczema by 3 years of age, the development of allergen skin test reactivity at 5 years of age, and the development of asthma at 5 and 8 years of age. Potential immunological mechanisms by which geohelminth infections may affect the study outcomes will be investigated also. DISCUSSION: The study will provide information on the potential effects of early exposures to geohelminths (during pregnancy and the first 2 years of life) on the development of vaccine immunity and allergy. The data will inform an ongoing debate of potential effects of geohelminths on child health and will contribute to policy decisions on new interventions designed to improve vaccine immunogenicity and protect against the development of allergic diseases.

Item Type: Article
Additional Information: © 2011 Cooper et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Keywords: Asthma, Child, Child, Preschool, Ecuador, Eczema, Epidemiologic Research Design, Female, Helminthiasis, Humans, Hypersensitivity, Immunity, Innate, Infant, Infant, Newborn, Longitudinal Studies, Models, Immunological, Pregnancy, Pregnancy Complications, Parasitic, Skin Tests, Vaccines, Science & Technology, Life Sciences & Biomedicine, Infectious Diseases, INTESTINAL HELMINTH INFECTIONS, ORAL POLIOVIRUS VACCINE, REGULATORY T-CELLS, CONCURRENT NEMATODE INFECTION, SKIN-TEST REACTIVITY, SCHOOL-AGE-CHILDREN, BLOOD-STAGE MALARIA, ASCARIS-LUMBRICOIDES, ATOPIC-DERMATITIS, CHOLERA VACCINE
SGUL Research Institute / Research Centre: Academic Structure > Infection and Immunity Research Institute (INII)
Academic Structure > Population Health Research Institute (INPH)
Journal or Publication Title: BMC INFECTIOUS DISEASES
ISSN: 1471-2334
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Dates:
DateEvent
29 June 2011Published
Web of Science ID: WOS:000292988100001
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URI: http://openaccess.sgul.ac.uk/id/eprint/350
Publisher's version: https://doi.org/10.1186/1471-2334-11-184

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