SORA

Advancing, promoting and sharing knowledge of health through excellence in teaching, clinical practice and research into the prevention and treatment of illness

Plasmodial sugar transporters as anti-malarial drug targets and comparisons with other protozoa.

Slavic, K; Krishna, S; Derbyshire, ET; Staines, HM (2011) Plasmodial sugar transporters as anti-malarial drug targets and comparisons with other protozoa. MALARIA JOURNAL, 10 (165). ISSN 1475-2875 https://doi.org/10.1186/1475-2875-10-165
SGUL Authors: Krishna, Sanjeev Staines, Henry Michael Slavic, Ksenija

[img]
Preview
PDF Published Version
Download (3MB) | Preview

Abstract

Glucose is the primary source of energy and a key substrate for most cells. Inhibition of cellular glucose uptake (the first step in its utilization) has, therefore, received attention as a potential therapeutic strategy to treat various unrelated diseases including malaria and cancers. For malaria, blood forms of parasites rely almost entirely on glycolysis for energy production and, without energy stores, they are dependent on the constant uptake of glucose. Plasmodium falciparum is the most dangerous human malarial parasite and its hexose transporter has been identified as being the major glucose transporter. In this review, recent progress regarding the validation and development of the P. falciparum hexose transporter as a drug target is described, highlighting the importance of robust target validation through both chemical and genetic methods. Therapeutic targeting potential of hexose transporters of other protozoan pathogens is also reviewed and discussed.

Item Type: Article
Additional Information: PubMed ID: 21676209 © 2011 Slavic et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Keywords: Animals, Antimalarials, Carbohydrate Metabolism, Drug Discovery, Humans, Monosaccharide Transport Proteins, Plasmodium falciparum, Science & Technology, Life Sciences & Biomedicine, Parasitology, Tropical Medicine, INTRAERYTHROCYTIC MALARIA PARASITE, FALCIPARUM-INFECTED ERYTHROCYTES, ARTEMISININ-RESISTANT MALARIA, GREEN TEA CATECHINS, HEXOSE TRANSPORTER, GLUCOSE-TRANSPORTER, LEISHMANIA-MEXICANA, LIFE-CYCLE, TRYPANOSOMA-BRUCEI, FUNCTIONAL-CHARACTERIZATION
SGUL Research Institute / Research Centre: Academic Structure > Infection and Immunity Research Institute (INII)
Journal or Publication Title: MALARIA JOURNAL
ISSN: 1475-2875
Related URLs:
Dates:
DateEvent
15 June 2011Published
Web of Science ID: WOS:000292704700001
Download EPMC Full text (PDF)
Download EPMC Full text (HTML)
URI: http://openaccess.sgul.ac.uk/id/eprint/30
Publisher's version: https://doi.org/10.1186/1475-2875-10-165

Actions (login required)

Edit Item Edit Item