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Hypertrophic cardiomyopathy and ultra-endurance running - two incompatible entities?

Wilson, MG; Chandra, N; Papadakis, M; O'Hanlon, R; Prasad, SK; Sharma, S (2011) Hypertrophic cardiomyopathy and ultra-endurance running - two incompatible entities? JOURNAL OF CARDIOVASCULAR MAGNETIC RESONANCE, 13 (77). pp. 1-9. ISSN 1097-6647
SGUL Authors: Papadakis, Michael Sharma, Sanjay

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Regular and prolonged exercise is associated with increased left ventricular wall thickness that can overlap with hypertrophic cardiomyopathy (HCM). Differentiating physiological from pathological hypertrophy has important implications, since HCM is the commonest cause of exercise-related sudden cardiac death in young individuals. Most deaths have been reported in intermittent 'start-stop' sports such as football (soccer) and basketball. The theory is that individuals with HCM are unable to augment stroke volume sufficiently to meet the demands of endurance sports and are accordingly 'selected-out' of participation in such events. We report the case of an ultra-endurance athlete with 25 years of > 50 km competitive running experience, with genetically confirmed HCM; thereby demonstrating that these can be two compatible entities.

Item Type: Article
Additional Information: © 2011 Wilson et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Keywords: Adult, Asymptomatic Diseases, Cardiomyopathy, Hypertrophic, Familial, Carrier Proteins, DNA Mutational Analysis, Echocardiography, Doppler, Color, Electrocardiography, Exercise Test, Genetic Predisposition to Disease, Humans, Magnetic Resonance Imaging, Male, Mutation, Phenotype, Physical Endurance, Running, Ultra-endurance exercise, hypertrophic cardiomyopathy, athlete's heart, sudden cardiac death, pre-participation screening, Science & Technology, Life Sciences & Biomedicine, Cardiac & Cardiovascular Systems, Radiology, Nuclear Medicine & Medical Imaging, Cardiovascular System & Cardiology, CARDIOVASCULAR MAGNETIC-RESONANCE, PHYSIOLOGICAL CARDIAC-HYPERTROPHY, LEFT-VENTRICULAR HYPERTROPHY, MYOCARDIAL FIBROSIS, SUDDEN-DEATH, ELECTROCARDIOGRAPHIC PATTERNS, CLINICAL-SIGNIFICANCE, PERICARDIAL DISEASES, COMPETITIVE SPORTS, ETHNIC-DIFFERENCES
SGUL Research Institute / Research Centre: Academic Structure > Molecular and Clinical Sciences Research Institute (MCS)
Academic Structure > Molecular and Clinical Sciences Research Institute (MCS) > Cardiac (INCCCA)
ISSN: 1097-6647
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29 November 2011Published
Web of Science ID: WOS:000298492800001
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