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Interval cancers in the NHS breast cancer screening programme in England, Wales and Northern Ireland.

Bennett, RL; Sellars, SJ; Moss, SM (2011) Interval cancers in the NHS breast cancer screening programme in England, Wales and Northern Ireland. British Journal of Cancer, 104 (4). 571 - 577. ISSN 0007-0920
SGUL Authors: Bennett, Rachel Louise

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Background: The United Kingdom NHS Breast Screening Programme was established in 1988, and women aged between 50 and 70 are routinely invited at three yearly intervals. Expected United Kingdom interval cancer rates have been calculated previously, but this is the first publication from an exercise to collate individual-based interval cancer data at a national level. Methods: Interval cancer case ascertainment is achieved by the regular exchange of data between Regional Breast Screening Quality Assurance Reference Centres and Cancer Registries. The present analysis includes interval cancers identified in women screened between 1st April 1997 and 31st March 2003, who were aged between 50 and 64 at the time of their last routine screen. Results: In the periods >0–<12 months, 12–<24 months and 24–<36 months after a negative screen, we found overall interval cancer rates and regional ranges of 0.55 (0.43–0.76), 1.13 (0.92–1.47) and 1.22 (0.93–1.57) per 1000 women screened, respectively. Rates in the period 33–<36 months showed a decline, possibly associated with early re-screening or delayed presentation. Conclusions: Interval cancer rates were higher than the expected rates in the 24-month period after a negative screen, but were similar to published results from other countries. Increases in background incidence may mean that the expected rates are underestimated. It is also possible that, as a result of incomplete case ascertainment, interval cancers rates were underestimated in some regions in which rates were less than the expected.

Item Type: Article
Additional Information: Copyright: 2011 Cancer Research UK From twelve months after its original publication, this work is licensed under the Creative Commons Attribution-NonCommercial-Share Alike 3.0 Unported License. To view a copy of this license, visit
Keywords: Aged, Algorithms, Breast Neoplasms, Carcinoma, Delayed Diagnosis, Early Detection of Cancer, England, Female, Humans, Incidence, Mammography, Middle Aged, Northern Ireland, Periodicity, Program Evaluation, Registries, Time Factors, Wales
Journal or Publication Title: British Journal of Cancer
ISSN: 0007-0920
4 October 2011Published
PubMed ID: 21285989
Web of Science ID: 21285989
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