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Interleukin 18 and coronary heart disease: Prospective study and systematic review

Jefferis, BJ; Papacosta, O; Owen, CG; Wannamethee, SG; Humphries, SE; Woodward, M; Lennon, LT; Thomson, A; Welsh, P; Rumley, A; et al. Jefferis, BJ; Papacosta, O; Owen, CG; Wannamethee, SG; Humphries, SE; Woodward, M; Lennon, LT; Thomson, A; Welsh, P; Rumley, A; Lowe, GD; Whincup, PH (2011) Interleukin 18 and coronary heart disease: Prospective study and systematic review. ATHEROSCLEROSIS, 217 (1). 227 - 233. ISSN 0021-9150 https://doi.org/10.1016/j.atherosclerosis.2011.03.015
SGUL Authors: Owen, Christopher Grant Whincup, Peter Hynes

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Abstract

Aim Previous studies suggest that circulating levels of interleukin-18 (IL-18) may be prospectively related to risk of coronary heart disease (CHD) in the general population. We report new data from the largest prospective study to date, which are combined with data from all published prospective studies in a meta-analysis. Methods We measured baseline IL-18 levels in stored serum samples of subjects from a case–control study nested within a prospective study of 5661 men aged 40–59 years recruited from general practices in 18 British towns in 1978–1980 and followed-up for up to 16 years (median time to event 8.4 years) for fatal CHD and non-fatal myocardial infarction (595 cases, 1238 controls). Results IL-18 concentrations were strongly related to cigarette smoking, triglyceride, HDL-cholesterol (inversely) and to circulating levels of several inflammatory and haemostatic markers. Men in the top third of baseline IL-18 levels had an age-adjusted odds ratio (OR) for CHD of 1.55 (95% CI 1.21, 1.98) compared with those in the lowest third; this was reduced to 1.30 (95% CI 0.99, 1.69) after additional adjustment for vascular risk factors and 1.12 (95% CI 0.84, 1.49) after further adjustment for CRP and IL-6. In meta-analyses of CVD, associations (or effect sizes) were consistent between studies; RRs were 1.63 (95% CI 1.46, 1.82) after age adjustment, 1.39 (95% CI 1.24, 1.55) after additional risk factor adjustment and 1.34 (95% CI 1.17, 1.54) after additional adjustment for inflammatory markers. Conclusions Circulating IL-18 is prospectively and independently associated with CVD risk.

Item Type: Article
Additional Information: Copyright © 2011 Elsevier Ireland Ltd. Under a Creative Commons license CC BY-NC-ND 3.0
Keywords: Adult, Case-Control Studies, Coronary Disease, Follow-Up Studies, Genotype, Great Britain, Humans, Inflammation, Interleukin-18, Middle Aged, Models, Statistical, Odds Ratio, Prospective Studies, Risk, Risk Factors, Science & Technology, Life Sciences & Biomedicine, Peripheral Vascular Disease, Cardiovascular System & Cardiology, C-REACTIVE PROTEIN, MIDDLE-AGED MEN, CARDIOVASCULAR-DISEASE, RISK-FACTORS, PROMOTER POLYMORPHISM, MYOCARDIAL-INFARCTION, REGRESSION DILUTION, MORGAM PROJECT, ARTERY-DISEASE, GENE, Coronary heart disease, Epidemiology, Interleukin-18, Cohort, Meta-analysis
SGUL Research Institute / Research Centre: Academic Structure > Population Health Research Institute (INPH)
Journal or Publication Title: ATHEROSCLEROSIS
ISSN: 0021-9150
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Dates:
DateEvent
1 July 2011Published
Web of Science ID: WOS:000292731300035
Download EPMC Full text (HTML)
URI: http://openaccess.sgul.ac.uk/id/eprint/2004
Publisher's version: https://doi.org/10.1016/j.atherosclerosis.2011.03.015

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