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The Role of Costimulatory Receptors of the Tumour Necrosis Factor Receptor Family in Atherosclerosis

Antunes, RF; Kaski, JC; Dumitriu, IE (2012) The Role of Costimulatory Receptors of the Tumour Necrosis Factor Receptor Family in Atherosclerosis. JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY, 2012 (464532). pp. 1-16. ISSN 1110-7243 https://doi.org/10.1155/2012/464532
SGUL Authors: Dumitriu, Ingrid Elena Kaski, Juan Carlos

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Abstract

Atherosclerosis is a chronic inflammatory disease that is mediated by both the innate and adaptive immune responses. T lymphocytes, that together with B cells are the cellular effectors of the adaptive immune system, are currently endowed with crucial roles in the development and progression of atherosclerosis. Costimulatory receptors are a class of molecules expressed by T lymphocytes that regulate the activation of T cells and the generation of effector T-cell responses. In this review we present the roles of costimulatory receptors of the tumour necrosis factor receptor (TNFR) superfamily in atherosclerosis and discuss the implications for future therapies that could be used to specifically modulate the immune response of pathogenic T cells in this disease.

Item Type: Article
Additional Information: Copyright © 2012 Ricardo F. Antunes et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Keywords: Antigens, CD, Atherosclerosis, B-Lymphocytes, Humans, Immune System, Lymphocyte Activation, Receptors, Tumor Necrosis Factor, T-Lymphocytes, Science & Technology, Life Sciences & Biomedicine, Biotechnology & Applied Microbiology, Medicine, Research & Experimental, Research & Experimental Medicine, BIOTECHNOLOGY & APPLIED MICROBIOLOGY, MEDICINE, RESEARCH & EXPERIMENTAL, REGULATORY T-CELLS, ACUTE CORONARY SYNDROMES, VASCULAR ENDOTHELIAL-CELLS, EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS, INFLAMMATORY-BOWEL-DISEASE, CORNEAL ALLOGRAFT SURVIVAL, HERPESVIRUS ENTRY MEDIATOR, ENHANCED PLASMA-LEVELS, INDUCED TNF RECEPTOR, SMOOTH-MUSCLE-CELLS
SGUL Research Institute / Research Centre: Academic Structure > Molecular and Clinical Sciences Research Institute (MCS)
Academic Structure > Molecular and Clinical Sciences Research Institute (MCS) > Cardiac (INCCCA)
Journal or Publication Title: JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY
ISSN: 1110-7243
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Dates:
DateEvent
1 January 2012Published
Web of Science ID: WOS:000298807300001
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URI: https://openaccess.sgul.ac.uk/id/eprint/1950
Publisher's version: https://doi.org/10.1155/2012/464532

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