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Carboxyhaemoglobin levels and their determinants in older British men

Whincup, P; Papacosta, O; Lennon, L; Haines, A (2006) Carboxyhaemoglobin levels and their determinants in older British men. BMC PUBLIC HEALTH, 6 (189). ISSN 1471-2458
SGUL Authors: Whincup, Peter Hynes

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Background: Although there has been concern about the levels of carbon monoxide exposure, particularly among older people, little is known about COHb levels and their determinants in the general population. We examined these issues in a study of older British men. Methods: Cross-sectional study of 4252 men aged 60–79 years selected from one socially representative general practice in each of 24 British towns and who attended for examination between 1998 and 2000. Blood samples were measured for COHb and information on social, household and individual factors assessed by questionnaire. Analyses were based on 3603 men measured in or close to (< 10 miles) their place of residence. Results: The COHb distribution was positively skewed. Geometric mean COHb level was 0.46% and the median 0.50%; 9.2% of men had a COHb level of 2.5% or more and 0.1% of subjects had a level of 7.5% or more. Factors which were independently related to mean COHb level included season (highest in autumn and winter), region (highest in Northern England), gas cooking (slight increase) and central heating (slight decrease) and active smoking, the strongest determinant. Mean COHb levels were more than ten times greater in men smoking more than 20 cigarettes a day (3.29%) compared with non-smokers (0.32%); almost all subjects with COHb levels of 2.5% and above were smokers (93%). Pipe and cigar smoking was associated with more modest increases in COHb level. Passive cigarette smoking exposure had no independent association with COHb after adjustment for other factors. Active smoking accounted for 41% of variance in COHb level and all factors together for 47%. Conclusion: An appreciable proportion of men have COHb levels of 2.5% or more at which symptomatic effects may occur, though very high levels are uncommon. The results confirm that smoking (particularly cigarette smoking) is the dominant influence on COHb levels.

Item Type: Article
Additional Information: © 2006 Whincup et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Keywords: Aged, Carbon Monoxide Poisoning, Carboxyhemoglobin, Cross-Sectional Studies, Dose-Response Relationship, Drug, Family Characteristics, Family Practice, Great Britain, Health Surveys, Humans, Male, Middle Aged, Prospective Studies, Questionnaires, Residence Characteristics, Risk Factors, Seasons, Smoking, Socioeconomic Factors, Time Factors, Science & Technology, Life Sciences & Biomedicine, Public, Environmental & Occupational Health, CONGESTIVE-HEART-FAILURE, CARBON-MONOXIDE EXPOSURE, CORONARY-ARTERY DISEASE, ASSOCIATION, PERFORMANCE, EXERCISE, SMOKERS, CITIES, RISK
SGUL Research Institute / Research Centre: Academic Structure > Population Health Research Institute (INPH)
Journal or Publication Title: BMC PUBLIC HEALTH
ISSN: 1471-2458
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18 July 2006Published
Web of Science ID: WOS:000240118700001
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