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Post-stenotic aortic dilatation.

Wilton, E; Jahangiri, M (2006) Post-stenotic aortic dilatation. JOURNAL OF CARDIOTHORACIC SURGERY, 1 (7). ISSN 1749-8090
SGUL Authors: Jahangiri, Marjan

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Aortic stenosis is the most common valvular heart disease affecting up to 4% of the elderly population. It can be associated with dilatation of the ascending aorta and subsequent dissection. Post-stenotic dilatation is seen in patients with AS and/or aortic regurgitation, patients with a haemodynamically normal bicuspid aortic valve and following aortic valve replacement. Controversy exists as to whether to replace the aortic root and ascending aorta at the time of aortic valve replacement, an operation that potentially carries a higher morbidity and mortality. The aetiology of post-stenotic aortic dilatation remains controversial. It may be due to haemodynamic factors caused by a stenotic valve, involving high velocity and turbulent flow downstream of the stenosis, or due to intrinsic pathology of the aortic wall. This may involve an abnormality in the process of extracellular matrix remodelling in the aortic wall including inadequate synthesis, degradation and transport of extracellular matrix proteins. This article reviews the aetiology, pathology and management of patients with post-stenotic aortic dilatation.

Item Type: Article
Additional Information: PubMed ID: 16722611 © 2006 Wilton and Jahangiri; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Keywords: Animals, Aorta, Thoracic, Aortic Diseases, Aortic Valve, Aortic Valve Stenosis, Comorbidity, Dilatation, Pathologic, Heart Defects, Congenital, Heart Valve Prosthesis Implantation, Hemodynamics, Humans, Matrix Metalloproteinases, Microfilament Proteins, Science & Technology, Life Sciences & Biomedicine, Cardiac & Cardiovascular Systems, Cardiovascular System & Cardiology
SGUL Research Institute / Research Centre: Academic Structure > Molecular and Clinical Sciences Research Institute (MCS)
Academic Structure > Molecular and Clinical Sciences Research Institute (MCS) > Cardiac (INCCCA)
ISSN: 1749-8090
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3 March 2006Published
Web of Science ID: WOS:000205613200007
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