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Genetics of common polygenic ischaemic stroke: current understanding and future challenges.

Bevan, S; Markus, HS (2011) Genetics of common polygenic ischaemic stroke: current understanding and future challenges. Stroke Research and Treatment, 2011 (179061). ISSN 2042-0056
SGUL Authors: Bevan, Stephen Nicholas Markus, Hugh Stephen

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Stroke is the third commonest cause of death and the major cause of adult neurological disability worldwide. While much is known about conventional risk factors such as hypertension, diabetes and incidence of smoking, these environmental factors only account for a proportion of stroke risk. Up to 50% of stroke risk can be attributed to genetic risk factors, although to date no single risk allele has been convincingly identified as contributing to this risk. Advances in the field of genetics, most notably genome wide association studies (GWAS), have revealed genetic risks in other cardiovascular disease and these techniques are now being applied to ischaemic stroke. This paper covers previous genetic studies in stroke including candidate gene studies, discusses the genome wide association approach, and future techniques such as next generation sequencing and the post-GWAS era. The review also considers the overlap from other cardiovascular diseases and whether findings from these may also be informative in ischaemic stroke.

Item Type: Article
Additional Information: Copyright © 2011 S. Bevan and H. S. Markus. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Journal or Publication Title: Stroke Research and Treatment
ISSN: 2042-0056
3 August 2011Published
PubMed ID: 21912753
Web of Science ID: 21912753
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