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A Hypnic Hypothesis of Alzheimer's Disease

Clark, CN; Warren, JD (2013) A Hypnic Hypothesis of Alzheimer's Disease. Neurodegenerative Diseases, 12 (4). pp. 165-176. ISSN 1660-2854 https://doi.org/10.1159/000350060
SGUL Authors: Clark, Camilla Neegaard

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Abstract

Background: Understanding the pathophysiology of Alzheimer's disease (AD) is of fundamental importance for improved diagnosis, monitoring and ultimately, treatment. Objective: A role for the sleep-wake cycle in the pathogenesis of AD has been proposed, but remains to be worked out in detail. Methods: Here we draw together several lines of previous work to outline a ‘hypnic hypothesis' of AD. Results: We propose that altered function of brainstem neurotransmitter pathways associated with sleep, promotes regionally specific disintegration of a cortico-subcortical ‘default mode' brain network that is selectively vulnerable in AD. Conclusion: The formation of a dynamic toxic state within this vulnerable network linked to sleep-wake disruption, would in turn lead to failure of synaptic repair, increased transmission of pathogenic misfolded proteins and a self-amplifying neurodegenerative process. We consider the evidence for this hypnic hypothesis and the implications that follow on from it.

Item Type: Article
Additional Information: © 2013 S. Karger AG, Basel This is an Open Access article licensed under the terms of the Creative Commons Attribution-NonCommercial 3.0 License (www.karger.com/OA-license-WT), applicable to the online version of the article only. Distribution for non-commercial purposes only.
Keywords: 1109 Neurosciences, 1103 Clinical Sciences, 1702 Cognitive Sciences, Neurology & Neurosurgery
SGUL Research Institute / Research Centre: Academic Structure > Molecular and Clinical Sciences Research Institute (MCS)
Journal or Publication Title: Neurodegenerative Diseases
ISSN: 1660-2854
Language: en
Dates:
DateEvent
October 2013Published
26 April 2013Published Online
19 February 2013Accepted
Publisher License: Creative Commons: Attribution-Noncommercial 3.0
Projects:
Project IDFunderFunder ID
091673/Z/10/ZWellcome Trusthttp://dx.doi.org/10.13039/100004440
UNSPECIFIEDMedical Research Councilhttp://dx.doi.org/10.13039/501100000265
URI: https://openaccess.sgul.ac.uk/id/eprint/112243
Publisher's version: https://doi.org/10.1159/000350060

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