SORA

Advancing, promoting and sharing knowledge of health through excellence in teaching, clinical practice and research into the prevention and treatment of illness

Invasive Streptococcus pyogenes Infections in <3-Month-Old Infants in France: Clinical and Laboratory Features.

Germont, Z; Bidet, P; Plainvert, C; Bonacorsi, S; Poyart, C; Biran, V; Frérot, A; Faye, A; Basmaci, R (2020) Invasive Streptococcus pyogenes Infections in <3-Month-Old Infants in France: Clinical and Laboratory Features. Front Pediatr, 8. p. 204. ISSN 2296-2360 https://doi.org/10.3389/fped.2020.00204
SGUL Authors: Basmaci, Romain

[img]
Preview
PDF Published Version
Available under License Creative Commons Attribution.

Download (254kB) | Preview

Abstract

Few data are available on invasive group A Streptococcus (GAS) infections (IGASIs) in infants. We described initial clinical and laboratory features and outcomes of <3-month-old infants hospitalized for an IGASI between 2007 and 2016 in France. Patients were identified from the French National Reference Centre for streptococci. IGASI was defined by the isolation of GAS from blood cultures or from other usually sterile sites. Data collection was performed by assessing the patients' hospitalization reports. Twenty-six patients (15 males; 57.7%) were included. Among 19 cases with available data, 14 (73.7%) were household contacts of a GAS infection, reaching 8/9 (88.9%) in neonates. The diagnoses were bacteremia (n = 18; 69.2%), pleural effusion or pneumonia (n = 6; 23.1%), meningitis with brain abscess (n = 1; 3.8%), and septic arthritis (n = 1; 3.8%). Fever (n = 10; 38.5%), hemodynamic disorders (n = 11; 42.3%), respiratory disorders (n = 7; 26.9%), thrombocytopenia (n = 7; 26.9%), and neutropenia (n = 5; 19.2%) were frequently observed. The main emm-genotype was emm-1 (n = 8; 30.8%). Thirteen (50.0%) infants have been admitted to the intensive care unit, and two (7.7%) died. Respiratory disorders, high C-reactive protein level, and the need for transfusion were significantly associated with severity. IGASI remains uncommon in <3-month-old children but leads to a high morbidity. Whether an antibiotic prophylaxis for contact neonates of a patient with GAS infection decreases the risk of infection remains to be determined.

Item Type: Article
Additional Information: Copyright © 2020 Germont, Bidet, Plainvert, Bonacorsi, Poyart, Biran, Frérot, Faye and Basmaci. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
Keywords: children, group A Streptococcus, invasive infection, neonatal infection, prophylaxis, group A Streptococcus, invasive infection, children, neonatal infection, prophylaxis
SGUL Research Institute / Research Centre: Academic Structure > Infection and Immunity Research Institute (INII)
Journal or Publication Title: Front Pediatr
ISSN: 2296-2360
Language: eng
Dates:
DateEvent
6 May 2020Published
3 April 2020Accepted
Publisher License: Creative Commons: Attribution 4.0
PubMed ID: 32435626
Web of Science ID: WOS:000536654000001
Go to PubMed abstract
URI: https://openaccess.sgul.ac.uk/id/eprint/112196
Publisher's version: https://doi.org/10.3389/fped.2020.00204

Actions (login required)

Edit Item Edit Item