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The role of whole genome sequencing in characterizing the mechanism of action of para-aminosalicylic acid and its resistance

Satta, G; Witney, AA; Begum, N; Canseco, JO; Boa, AN; McHugh, TD (2020) The role of whole genome sequencing in characterizing the mechanism of action of para-aminosalicylic acid and its resistance. Antimicrobial Agents and Chemotherapy, 64 (9). e00675-20. ISSN 0066-4804 https://doi.org/10.1128/AAC.00675-20
SGUL Authors: Witney, Adam Austin

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Abstract

para-Aminosalicylic acid (PAS) remains one of the drugs of last resort for the treatment of tuberculosis, but its mechanism of action is still not completely understood. The main aim of this project was to identify new potential mechanisms of action and resistance to PAS by performing whole-genome sequencing on PAS-resistant laboratory mutants. A new variant in the folC gene was identified, as well as some other mutations that require further study.

Item Type: Article
Additional Information: Copyright © 2020 American Society for Microbiology, Antimicrob. Agents Chemother., 64, 2020, 00675-20, DOI:10.1128/AAC.00675-20
Keywords: 0605 Microbiology, 1108 Medical Microbiology, 1115 Pharmacology and Pharmaceutical Sciences, Microbiology
SGUL Research Institute / Research Centre: Academic Structure > Infection and Immunity Research Institute (INII)
Journal or Publication Title: Antimicrobial Agents and Chemotherapy
ISSN: 0066-4804
Dates:
DateEvent
20 August 2020Published
22 June 2020Published Online
13 June 2020Accepted
Publisher License: Publisher's own licence
URI: https://openaccess.sgul.ac.uk/id/eprint/112044
Publisher's version: https://doi.org/10.1128/AAC.00675-20

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