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A core outcome set for pre‐eclampsia research: an international consensus development study

Duffy, J; Cairns, AE; Richards-Doran, D; van 't Hooft, J; Gale, C; Brown, M; Chappell, LC; Grobman, WA; Fitzpatrick, R; Karumanchi, SA; et al. Duffy, J; Cairns, AE; Richards-Doran, D; van 't Hooft, J; Gale, C; Brown, M; Chappell, LC; Grobman, WA; Fitzpatrick, R; Karumanchi, SA; Khalil, A; Lucas, DN; Magee, LA; Mol, BW; Stark, M; Thangaratinam, S; Wilson, MJ; von Dadelszen, P; Williamson, PR; Ziebland, S; McManus, RJ; International Collaboration to Harmonise Outcomes for Pre-eclamp (2020) A core outcome set for pre‐eclampsia research: an international consensus development study. BJOG, 127 (12). pp. 1516-1526. ISSN 1471-0528 https://doi.org/10.1111/1471-0528.16319
SGUL Authors: Khalil, Asma

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Abstract

Objective To develop a core outcome set for pre‐eclampsia. Design Consensus development study. Setting International. Population Two hundred and eight‐one healthcare professionals, 41 researchers and 110 patients, representing 56 countries, participated. Methods Modified Delphi method and Modified Nominal Group Technique. Results A long‐list of 116 potential core outcomes was developed by combining the outcomes reported in 79 pre‐eclampsia trials with those derived from thematic analysis of 30 in‐depth interviews of women with lived experience of pre‐eclampsia. Forty‐seven consensus outcomes were identified from the Delphi process following which 14 maternal and eight offspring core outcomes were agreed at the consensus development meeting. Maternal core outcomes: death, eclampsia, stroke, cortical blindness, retinal detachment, pulmonary oedema, acute kidney injury, liver haematoma or rupture, abruption, postpartum haemorrhage, raised liver enzymes, low platelets, admission to intensive care required, and intubation and ventilation. Offspring core outcomes: stillbirth, gestational age at delivery, birthweight, small‐for‐gestational‐age, neonatal mortality, seizures, admission to neonatal unit required and respiratory support. Conclusions The core outcome set for pre‐eclampsia should underpin future randomised trials and systematic reviews. Such implementation should ensure that future research holds the necessary reach and relevance to inform clinical practice, enhance women's care and improve the outcomes of pregnant women and their babies.

Item Type: Article
Additional Information: © 2020 The Authors. BJOG: An International Journal of Obstetrics and Gynaecology published by John Wiley & Sons Ltd on behalf of Royal College of Obstetricians and Gynaecologists This is an open access article under the terms of the Creative Commons Attribution (http://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Keywords: Consensus development study, core outcome set, modified Delphi method, modified nominal group technique, outcome reporting bias, pre-eclampsia, International Collaboration to Harmonise Outcomes for Pre-eclampsia (iHOPE), 11 Medical and Health Sciences, Obstetrics & Reproductive Medicine
SGUL Research Institute / Research Centre: Academic Structure > Molecular and Clinical Sciences Research Institute (MCS)
Journal or Publication Title: BJOG
ISSN: 1471-0528
Language: eng
Dates:
DateEvent
9 October 2020Published
21 June 2020Published Online
11 May 2020Accepted
Publisher License: Creative Commons: Attribution 4.0
Projects:
Project IDFunderFunder ID
UNSPECIFIEDBarts CharityUNSPECIFIED
UNSPECIFIEDElisabeth Garrett Anderson Hospital Charity Travelling Fellowship in Memory of Anne BoutwoodUNSPECIFIED
DRF-2014-07-051National Institute for Health Researchhttp://dx.doi.org/10.13039/501100000272
NIHR-RP- R2-12-015National Institute for Health Researchhttp://dx.doi.org/10.13039/501100000272
PubMed ID: 32416644
Go to PubMed abstract
URI: https://openaccess.sgul.ac.uk/id/eprint/111964
Publisher's version: https://doi.org/10.1111/1471-0528.16319

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