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Recreational marathon running does not cause exercise-induced left ventricular hypertrabeculation.

D'Silva, A; Captur, G; Bhuva, AN; Jones, S; Bastiaenen, R; Abdel-Gadir, A; Gati, S; van Zalen, J; Willis, J; Malhotra, A; et al. D'Silva, A; Captur, G; Bhuva, AN; Jones, S; Bastiaenen, R; Abdel-Gadir, A; Gati, S; van Zalen, J; Willis, J; Malhotra, A; Ster, IC; Manisty, C; Hughes, AD; Lloyd, G; Sharma, R; Moon, JC; Sharma, S (2020) Recreational marathon running does not cause exercise-induced left ventricular hypertrabeculation. Int J Cardiol, 315. pp. 67-71. ISSN 1874-1754 https://doi.org/10.1016/j.ijcard.2020.04.081
SGUL Authors: Sharma, Sanjay Chis Ster, Delizia Irina

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Abstract

BACKGROUND: Marathon running in novices represents a natural experiment of short-term cardiovascular remodeling in response to running training. We examine whether this stimulus can produce exercise-induced left ventricular (LV) trabeculation. METHODS: Sixty-eight novice marathon runners aged 29.5 ± 3.2 years had indices of LV trabeculation measured by echocardiography and cardiac magnetic resonance imaging 6 months before and 2 weeks after the 2016 London Marathon race, in a prospective longitudinal study. RESULTS: After 17 weeks unsupervised marathon training, indices of LV trabeculation were essentially unchanged. Despite satisfactory inter-observer agreement in most methods of trabeculation measurement, criteria defining abnormally hypertrabeculated cases were discordant with each other. LV hypertrabeculation was a frequent finding in young, healthy individuals with no subject demonstrating clear evidence of a cardiomyopathy. CONCLUSION: Training for a first marathon does not induce LV trabeculation. It remains unclear whether prolonged, high-dose exercise can create de novo trabeculation or expose concealed trabeculation. Applying cut off values from published LV noncompaction cardiomyopathy criteria to young, healthy individuals risks over-diagnosis.

Item Type: Article
Additional Information: © 2020 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
Keywords: 1102 Cardiorespiratory Medicine and Haematology, Cardiovascular System & Hematology
SGUL Research Institute / Research Centre: Academic Structure > Infection and Immunity Research Institute (INII)
Academic Structure > Molecular and Clinical Sciences Research Institute (MCS)
Journal or Publication Title: Int J Cardiol
ISSN: 1874-1754
Language: eng
Dates:
DateEvent
15 September 2020Published
27 April 2020Accepted
Publisher License: Creative Commons: Attribution 4.0
Projects:
Project IDFunderFunder ID
FS/15/27/31465British Heart Foundationhttp://dx.doi.org/10.13039/501100000274
PubMed ID: 32360651
Go to PubMed abstract
URI: https://openaccess.sgul.ac.uk/id/eprint/111942
Publisher's version: https://doi.org/10.1016/j.ijcard.2020.04.081

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