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Low Sensitivity of BinaxNOW RSV in Infants.

Zuurbier, RP; Bont, LJ; Langedijk, AC; Hamer, M; Korsten, K; Drysdale, SB; Snape, MD; Robinson, H; Pollard, AJ; Martinón-Torres, F; et al. Zuurbier, RP; Bont, LJ; Langedijk, AC; Hamer, M; Korsten, K; Drysdale, SB; Snape, MD; Robinson, H; Pollard, AJ; Martinón-Torres, F; Rodríguez-Tenreiro Sánchez, C; Gómez-Carballa, A; Dacosta-Urbieta, AI; Heikkinen, T; Cunningham, S; van Houten, MA; Wildenbeest, JG; RESCEU Investigators (2020) Low Sensitivity of BinaxNOW RSV in Infants. J Infect Dis, 222 (Supplement 7). S640-S647. ISSN 1537-6613 https://doi.org/10.1093/infdis/jiaa050
SGUL Authors: Drysdale, Simon Bruce

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Abstract

BACKGROUND: Respiratory syncytial virus (RSV) is a major cause of hospitalization in infants. Early detection of RSV can optimize clinical management and minimize use of antibiotics. BinaxNOW RSV (BN) is a rapid antigen detection test that is widely used. We aimed to validate the sensitivity of BN in hospitalized and nonhospitalized infants against the gold standard of molecular diagnosis. METHODS: We evaluated the performance of BN in infants with acute respiratory tract infections with different degrees of disease severity. Diagnostic accuracy of BN test results were compared with molecular diagnosis as reference standard. RESULTS: One hundred sixty-two respiratory samples from 148 children from October 2017 to February 2019 were studied. Sixty-six (40.7%) samples tested positive for RSV (30 hospitalizations, 31 medically attended episodes not requiring hospitalization, and 5 nonmedically attended episodes). Five of these samples tested positive with BN, leading to an overall sensitivity of BN of 7.6% (95% confidence interval [CI], 3.3%-16.5%) and a specificity of 100% (95% CI, 96.2%-100%). Sensitivity was low in all subgroups. CONCLUSIONS: We found a low sensitivity of BN for point-of-care detection of RSV infection. BinaxNOW RSV should be used and interpreted with caution.

Item Type: Article
Additional Information: This is a pre-copyedited, author-produced version of an article accepted for publication in The Journal of Infectious Diseases following peer review. The version of record Roy P Zuurbier, Louis J Bont, Annefleur C Langedijk, Mirjam Hamer, Koos Korsten, Simon B Drysdale, Matthew D Snape, Hannah Robinson, Andrew J Pollard, Federico Martinón-Torres, Carmen Rodríguez-Tenreiro Sánchez, Alberto Gómez-Carballa, Ana Isabel Dacosta-Urbieta, Terho Heikkinen, Steve Cunningham, Marlies A van Houten, Joanne G Wildenbeest, RESCEU Investigators, Low Sensitivity of BinaxNOW RSV in Infants, The Journal of Infectious Diseases, Volume 222, Issue Supplement_7, 1 November 2020, Pages S640–S647 is available online at: https://doi.org/10.1093/infdis/jiaa050
Keywords: antigen detection, birth cohort, diagnosis, point-of-care test, respiratory syncytial virus, RESCEU Investigators, 11 Medical and Health Sciences, 06 Biological Sciences, Microbiology
SGUL Research Institute / Research Centre: Academic Structure > Infection and Immunity Research Institute (INII)
Journal or Publication Title: J Infect Dis
ISSN: 1537-6613
Language: eng
Dates:
DateEvent
1 November 2020Published
30 March 2020Published Online
9 February 2020Accepted
Publisher License: Publisher's own licence
Projects:
Project IDFunderFunder ID
116019Innovative Medicines InitiativeUNSPECIFIED
PubMed ID: 32227106
Go to PubMed abstract
URI: https://openaccess.sgul.ac.uk/id/eprint/111898
Publisher's version: https://doi.org/10.1093/infdis/jiaa050

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