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Antimicrobial Activity of the Quinoline Derivative HT61 against Staphylococcus aureus Biofilms.

Frapwell, CJ; Skipp, PJ; Howlin, RP; Angus, EM; Hu, Y; Coates, ARM; Allan, RN; Webb, JS (2020) Antimicrobial Activity of the Quinoline Derivative HT61 against Staphylococcus aureus Biofilms. Antimicrob Agents Chemother, 64 (5). ISSN 1098-6596 https://doi.org/10.1128/AAC.02073-19
SGUL Authors: Coates, Anthony Robert Milnes Hu, Yanmin

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Abstract

Staphylococcus aureus biofilms are a significant problem in health care settings, partly due to the presence of a nondividing, antibiotic-tolerant subpopulation. Here we evaluated treatment of S. aureus UAMS-1 biofilms with HT61, a quinoline derivative shown to be effective against nondividing Staphylococcus spp. HT61 was effective at reducing biofilm viability and was associated with increased expression of cell wall stress and division proteins, confirming its potential as a treatment for S. aureus biofilm infections.

Item Type: Article
Additional Information: Copyright © 2020 Frapwell et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license (https://creativecommons.org/licenses/by/4.0/).
Keywords: HT61, Staphylococcus aureus, antibiotics, biofilms, proteomics, HT61, Staphylococcus aureus, antibiotics, biofilms, proteomics, 0605 Microbiology, 1108 Medical Microbiology, 1115 Pharmacology and Pharmaceutical Sciences, Microbiology
SGUL Research Institute / Research Centre: Academic Structure > Infection and Immunity Research Institute (INII)
Journal or Publication Title: Antimicrob Agents Chemother
ISSN: 1098-6596
Language: eng
Dates:
DateEvent
May 2020Published
21 April 2020Published Online
25 February 2020Accepted
Publisher License: Creative Commons: Attribution 4.0
Projects:
Project IDFunderFunder ID
BB/L016877/1Biotechnology and Biological Sciences Research Councilhttp://dx.doi.org/10.13039/501100000268
BM/M012387/1Biotechnology and Biological Sciences Research Councilhttp://dx.doi.org/10.13039/501100000268
UNSPECIFIEDWessex Medical TrustUNSPECIFIED
PubMed ID: 32122902
Web of Science ID: WOS:000528256200033
Go to PubMed abstract
URI: http://openaccess.sgul.ac.uk/id/eprint/111774
Publisher's version: https://doi.org/10.1128/AAC.02073-19

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