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Network neuroscience of apathy in cerebrovascular disease.

Tay, J; Lisiecka-Ford, DM; Hollocks, MJ; Tuladhar, AM; Barrick, TR; Forster, A; O'Sullivan, MJ; Husain, M; de Leeuw, F-E; Morris, RG; et al. Tay, J; Lisiecka-Ford, DM; Hollocks, MJ; Tuladhar, AM; Barrick, TR; Forster, A; O'Sullivan, MJ; Husain, M; de Leeuw, F-E; Morris, RG; Markus, HS (2020) Network neuroscience of apathy in cerebrovascular disease. Prog Neurobiol, 188. p. 101785. ISSN 1873-5118 https://doi.org/10.1016/j.pneurobio.2020.101785
SGUL Authors: Barrick, Thomas Richard

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Abstract

Apathy is a reduction in motivated goal-directed behavior (GDB) that is prevalent in cerebrovascular disease, providing an important opportunity to study the mechanistic underpinnings of motivation in humans. Focal lesions, such as those seen in stroke, have been crucial in developing models of brain regions underlying motivated behavior, while studies of cerebral small vessel disease (SVD) have helped define the connections between brain regions supporting such behavior. However, current lesion-based models cannot fully explain the neurobiology of apathy in stroke and SVD. To address this, we propose a network-based model which conceptualizes apathy as the result of damage to GDB-related networks. A review of the current evidence suggests that cerebrovascular disease-related pathology can lead to network changes outside of initially damaged territories, which may propagate to regions that share structural or functional connections. The presentation and longitudinal trajectory of apathy in stroke and SVD may be the result of these network changes. Distinct subnetworks might support cognitive components of GDB, the disruption of which results in specific symptoms of apathy. This network-based model of apathy may open new approaches for investigating its underlying neurobiology, and presents novel opportunities for its diagnosis and treatment.

Item Type: Article
Additional Information: © 2020. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
Keywords: apathy, cerebral small vessel disease, cerebrovascular disease, cognition, networks, stroke, 1109 Neurosciences, 1702 Cognitive Sciences, Neurology & Neurosurgery
SGUL Research Institute / Research Centre: Academic Structure > Molecular and Clinical Sciences Research Institute (MCS)
Journal or Publication Title: Prog Neurobiol
ISSN: 1873-5118
Language: eng
Dates:
DateEvent
May 2020Published
6 March 2020Published Online
3 March 2020Accepted
Publisher License: Creative Commons: Attribution-Noncommercial-No Derivative Works 4.0
Projects:
Project IDFunderFunder ID
PPA 2015-02Stroke Associationhttp://dx.doi.org/10.13039/501100000364
146281National Institute for Health Researchhttp://dx.doi.org/10.13039/501100000272
2016T044Dutch Heart FoundationUNSPECIFIED
016-126-351ZonMWUNSPECIFIED
2014T060Dutch Heart FoundationUNSPECIFIED
098282Wellcome Trusthttp://dx.doi.org/10.13039/100004440
PubMed ID: 32151533
Go to PubMed abstract
URI: http://openaccess.sgul.ac.uk/id/eprint/111770
Publisher's version: https://doi.org/10.1016/j.pneurobio.2020.101785

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