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Congenital Cytomegalovirus Infection: A Narrative Review of the Issues in Screening and Management From a Panel of European Experts.

Lazzarotto, T; Blázquez-Gamero, D; Delforge, M-L; Foulon, I; Luck, S; Modrow, S; Leruez-Ville, M (2020) Congenital Cytomegalovirus Infection: A Narrative Review of the Issues in Screening and Management From a Panel of European Experts. Front Pediatr, 8. p. 13. ISSN 2296-2360 https://doi.org/10.3389/fped.2020.00013
SGUL Authors: Luck, Suzanne Elizabeth

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Abstract

Maternal primary and non-primary cytomegalovirus (CMV) infection during pregnancy can result in in utero transmission to the developing fetus. Congenital CMV (cCMV) can result in significant morbidity, mortality or long-term sequelae, including sensorineural hearing loss, the most common sequela. As a leading cause of congenital infections worldwide, cCMV infection meets many of the criteria for screening. However, currently there are no universal programs that offer maternal or neonatal screening to identify infected mothers and infants, no vaccines to prevent infection, and no efficacious and safe therapies available for the treatment of maternal or fetal CMV infection. Data has shown that there are several maternal and neonatal screening strategies, and diagnostic methodologies, that allow the identification of those at risk of developing sequelae and adequately detect cCMV. Nevertheless, many questions remain unanswered in this field. Well-designed clinical trials to address several facets of CMV treatment (in pregnant women, CMV-infected fetuses and both symptomatic and asymptomatic neonates and children) are required. Prevention (vaccines), biology and transmission factors associated with non-primary CMV, and the cost-effectiveness of universal screening, all demand further exploration to fully realize the ultimate goal of preventing cCMV. In the meantime, prevention of primary infection during pregnancy should be championed to all by means of hygiene education.

Item Type: Article
Additional Information: Copyright © 2020 Lazzarotto, Blázquez-Gamero, Delforge, Foulon, Luck, Modrow and Leruez-Ville. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
Keywords: clinical laboratory techniques, congenital CMV, cytomegalovirus, maternal screening, neonatal screening, pregnancy, prenatal diagnosis
SGUL Research Institute / Research Centre: Academic Structure > Infection and Immunity Research Institute (INII)
Journal or Publication Title: Front Pediatr
ISSN: 2296-2360
Language: eng
Dates:
DateEvent
31 January 2020Published
10 January 2020Accepted
Publisher License: Creative Commons: Attribution 4.0
PubMed ID: 32083040
Go to PubMed abstract
URI: http://openaccess.sgul.ac.uk/id/eprint/111760
Publisher's version: https://doi.org/10.3389/fped.2020.00013

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